صورة الغلاف

The Effects of Honey on Inflammatory Cells in Cigarette Smoke Affected Lungs in Rats: A Preliminary Study

Chronic Obstructive Pulmonary Disease (COPD) is a global significant health-delinquent. Inflammatory changes signify a clear indication in the early pathological changes of the airway in this disease and cigarette smoking is the most common risk factor. The ultimate goal in COPD is prevention. Rec...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Tg Fatimah Murniwati, Tengku Muda, Mainul, Haque, Nordin, Simbak
التنسيق: مقال
اللغة:English
English
منشور في: 2014
الموضوعات:
QH301 Biology
الوصول للمادة أونلاين:http://eprints.unisza.edu.my/5663/1/FH02-FP-15-03089.pdf
http://eprints.unisza.edu.my/5663/2/FH02-FP-16-05366.jpg
http://eprints.unisza.edu.my/5663/
الوسوم: إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
id my-unisza-ir.5663
record_format eprints
spelling my-unisza-ir.56632022-09-13T04:47:00Z http://eprints.unisza.edu.my/5663/ The Effects of Honey on Inflammatory Cells in Cigarette Smoke Affected Lungs in Rats: A Preliminary Study Tg Fatimah Murniwati, Tengku Muda Mainul, Haque Nordin, Simbak QH301 Biology Chronic Obstructive Pulmonary Disease (COPD) is a global significant health-delinquent. Inflammatory changes signify a clear indication in the early pathological changes of the airway in this disease and cigarette smoking is the most common risk factor. The ultimate goal in COPD is prevention. Recently, honey has been shown to have significant therapeutic possessions. The objective of this study was to evaluate the effect of honey on the inflammatory process in small airways of rats exposed to cigarette smoke. Twenty-three male rats between 8-9 weeks old were randomly divided into 3 groups. The first group was exposed daily to cigarette smoke alone using smoking apparatus. The second group was exposed to smoke and given oral honey at 1.2gm/kg body weight daily and the third group was assigned as control. The rats were sacrificed after four weeks of exposure and the lung tissues were processed accordingly. The sections were immunohistochemical stained with anti-CD68 and anti-CD8 for macrophages and CD8+ T lymphocytes counts. There was a significant reduction in the number of macrophages in the group exposed to cigarette smoke with honey compared to smoke exposure alone (z=-2.52, p= 0.012). However there was no significant reduction in the number of CD8+ T lymphocytes counts between the two groups (z=-0.40, p=0.690). Current study found honey has a prospective effect in reducing the macrophage recruitment in airways following inflammatory response due to cigarette smoke inhalations. 2014-12 Article PeerReviewed text en http://eprints.unisza.edu.my/5663/1/FH02-FP-15-03089.pdf image en http://eprints.unisza.edu.my/5663/2/FH02-FP-16-05366.jpg Tg Fatimah Murniwati, Tengku Muda and Mainul, Haque and Nordin, Simbak (2014) The Effects of Honey on Inflammatory Cells in Cigarette Smoke Affected Lungs in Rats: A Preliminary Study. Research Journal of Pharmacy and Technology, 7 (12). pp. 1382-1386. ISSN 0974-3618
institution Universiti Sultan Zainal Abidin
building UNISZA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sultan Zainal Abidin
content_source UNISZA Institutional Repository
url_provider https://eprints.unisza.edu.my/
language English
English
topic QH301 Biology
spellingShingle QH301 Biology
Tg Fatimah Murniwati, Tengku Muda
Mainul, Haque
Nordin, Simbak
The Effects of Honey on Inflammatory Cells in Cigarette Smoke Affected Lungs in Rats: A Preliminary Study
description Chronic Obstructive Pulmonary Disease (COPD) is a global significant health-delinquent. Inflammatory changes signify a clear indication in the early pathological changes of the airway in this disease and cigarette smoking is the most common risk factor. The ultimate goal in COPD is prevention. Recently, honey has been shown to have significant therapeutic possessions. The objective of this study was to evaluate the effect of honey on the inflammatory process in small airways of rats exposed to cigarette smoke. Twenty-three male rats between 8-9 weeks old were randomly divided into 3 groups. The first group was exposed daily to cigarette smoke alone using smoking apparatus. The second group was exposed to smoke and given oral honey at 1.2gm/kg body weight daily and the third group was assigned as control. The rats were sacrificed after four weeks of exposure and the lung tissues were processed accordingly. The sections were immunohistochemical stained with anti-CD68 and anti-CD8 for macrophages and CD8+ T lymphocytes counts. There was a significant reduction in the number of macrophages in the group exposed to cigarette smoke with honey compared to smoke exposure alone (z=-2.52, p= 0.012). However there was no significant reduction in the number of CD8+ T lymphocytes counts between the two groups (z=-0.40, p=0.690). Current study found honey has a prospective effect in reducing the macrophage recruitment in airways following inflammatory response due to cigarette smoke inhalations.
format Article
author Tg Fatimah Murniwati, Tengku Muda
Mainul, Haque
Nordin, Simbak
author_facet Tg Fatimah Murniwati, Tengku Muda
Mainul, Haque
Nordin, Simbak
author_sort Tg Fatimah Murniwati, Tengku Muda
title The Effects of Honey on Inflammatory Cells in Cigarette Smoke Affected Lungs in Rats: A Preliminary Study
title_short The Effects of Honey on Inflammatory Cells in Cigarette Smoke Affected Lungs in Rats: A Preliminary Study
title_full The Effects of Honey on Inflammatory Cells in Cigarette Smoke Affected Lungs in Rats: A Preliminary Study
title_fullStr The Effects of Honey on Inflammatory Cells in Cigarette Smoke Affected Lungs in Rats: A Preliminary Study
title_full_unstemmed The Effects of Honey on Inflammatory Cells in Cigarette Smoke Affected Lungs in Rats: A Preliminary Study
title_sort effects of honey on inflammatory cells in cigarette smoke affected lungs in rats: a preliminary study
publishDate 2014
url http://eprints.unisza.edu.my/5663/1/FH02-FP-15-03089.pdf
http://eprints.unisza.edu.my/5663/2/FH02-FP-16-05366.jpg
http://eprints.unisza.edu.my/5663/
_version_ 1744358534522339328
score 13.251813

مواد مشابهة