The Effects of Honey on Inflammatory Cells in Cigarette Smoke Affected Lungs in Rats: A Preliminary Study
Chronic Obstructive Pulmonary Disease (COPD) is a global significant health-delinquent. Inflammatory changes signify a clear indication in the early pathological changes of the airway in this disease and cigarette smoking is the most common risk factor. The ultimate goal in COPD is prevention. Rec...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English English |
| Published: |
2014
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| Subjects: | |
| Online Access: | http://eprints.unisza.edu.my/5663/1/FH02-FP-15-03089.pdf http://eprints.unisza.edu.my/5663/2/FH02-FP-16-05366.jpg http://eprints.unisza.edu.my/5663/ |
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| Summary: | Chronic Obstructive Pulmonary Disease (COPD) is a global significant health-delinquent. Inflammatory changes
signify a clear indication in the early pathological changes of the airway in this disease and cigarette smoking is the
most common risk factor. The ultimate goal in COPD is prevention. Recently, honey has been shown to have
significant therapeutic possessions. The objective of this study was to evaluate the effect of honey on the inflammatory
process in small airways of rats exposed to cigarette smoke. Twenty-three male rats between 8-9 weeks old were
randomly divided into 3 groups. The first group was exposed daily to cigarette smoke alone using smoking apparatus.
The second group was exposed to smoke and given oral honey at 1.2gm/kg body weight daily and the third group was
assigned as control. The rats were sacrificed after four weeks of exposure and the lung tissues were processed
accordingly. The sections were immunohistochemical stained with anti-CD68 and anti-CD8 for macrophages and
CD8+ T lymphocytes counts. There was a significant reduction in the number of macrophages in the group exposed to
cigarette smoke with honey compared to smoke exposure alone (z=-2.52, p= 0.012). However there was no significant
reduction in the number of CD8+ T lymphocytes counts between the two groups (z=-0.40, p=0.690). Current study
found honey has a prospective effect in reducing the macrophage recruitment in airways following inflammatory
response due to cigarette smoke inhalations. |
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