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Effects of Leptin gene variants on obesity and its attributes in Malay population

Leptin is a hormone that regulates the energy intake and expenditure which is encoded by leptin gene. Leptin gene variants were studied comprehensively in relation with body weight status, but the evidences were indecisive. This study was to determine the association between leptin gene variants,...

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Main Author: Wan Rohani, Wan Taib
Format: Article
Language:English
Published: 2018
Subjects:
R Medicine (General)
Online Access:http://eprints.unisza.edu.my/5610/1/FH02-FSK-19-28410-1.pdf
http://eprints.unisza.edu.my/5610/
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spelling my-unisza-ir.56102022-02-22T02:11:04Z http://eprints.unisza.edu.my/5610/ Effects of Leptin gene variants on obesity and its attributes in Malay population Wan Rohani, Wan Taib R Medicine (General) Leptin is a hormone that regulates the energy intake and expenditure which is encoded by leptin gene. Leptin gene variants were studied comprehensively in relation with body weight status, but the evidences were indecisive. This study was to determine the association between leptin gene variants, G2548A, H1328080 and A19G with obesity and its attributes in Terengganu, Malaysian population. This study involved a total of 249 Malay subjects (101 healthy adults with normal BMI as the control group and 148 overweight and obese subjects). The anthropometrics data were obtained, blood samples were collected for genetic markers and lipid profile analyses. PCR-RFLP technique was performed to determine the genotype and allele distribution of leptin gene variants. The genotypic and allelic frequencies of leptin gene variants presented no significant difference between groups, G2548A (P = 0.93 and 0.74); H1328080 (P = 0.58 and 0.56); and A19G (P = 0.72 and 0.38) correspondingly. However, there was statistical significant difference between triglyceride level and genotypes of G2548A variant (P = 0.016); between total cholesterol level and H1328080 genotypes (P = 0.027). In addition, multivariate logistic regression projected the male gender (adjusted OR= 26.27; CI= 1.06-1.25; P = 0.009), waist circumference (adjusted OR = 1.15; CI = 1.06-1.25; P = 0.001) and body fat percentage (adjusted OR = 1.43; CI = 1.20-1.70; P<0.001) were the independent risk factors for obesity. The data suggest G2548A, H1328080 and A19G variants were not associated with obesity. However, waist circumference and body fat percentage may increase risk for obesity in Malay population. 2018-10 Article PeerReviewed text en http://eprints.unisza.edu.my/5610/1/FH02-FSK-19-28410-1.pdf Wan Rohani, Wan Taib (2018) Effects of Leptin gene variants on obesity and its attributes in Malay population. Med & Health, 13 (2). pp. 58-71. ISSN 2289-5728
institution Universiti Sultan Zainal Abidin
building UNISZA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sultan Zainal Abidin
content_source UNISZA Institutional Repository
url_provider https://eprints.unisza.edu.my/
language English
topic R Medicine (General)
spellingShingle R Medicine (General)
Wan Rohani, Wan Taib
Effects of Leptin gene variants on obesity and its attributes in Malay population
description Leptin is a hormone that regulates the energy intake and expenditure which is encoded by leptin gene. Leptin gene variants were studied comprehensively in relation with body weight status, but the evidences were indecisive. This study was to determine the association between leptin gene variants, G2548A, H1328080 and A19G with obesity and its attributes in Terengganu, Malaysian population. This study involved a total of 249 Malay subjects (101 healthy adults with normal BMI as the control group and 148 overweight and obese subjects). The anthropometrics data were obtained, blood samples were collected for genetic markers and lipid profile analyses. PCR-RFLP technique was performed to determine the genotype and allele distribution of leptin gene variants. The genotypic and allelic frequencies of leptin gene variants presented no significant difference between groups, G2548A (P = 0.93 and 0.74); H1328080 (P = 0.58 and 0.56); and A19G (P = 0.72 and 0.38) correspondingly. However, there was statistical significant difference between triglyceride level and genotypes of G2548A variant (P = 0.016); between total cholesterol level and H1328080 genotypes (P = 0.027). In addition, multivariate logistic regression projected the male gender (adjusted OR= 26.27; CI= 1.06-1.25; P = 0.009), waist circumference (adjusted OR = 1.15; CI = 1.06-1.25; P = 0.001) and body fat percentage (adjusted OR = 1.43; CI = 1.20-1.70; P<0.001) were the independent risk factors for obesity. The data suggest G2548A, H1328080 and A19G variants were not associated with obesity. However, waist circumference and body fat percentage may increase risk for obesity in Malay population.
format Article
author Wan Rohani, Wan Taib
author_facet Wan Rohani, Wan Taib
author_sort Wan Rohani, Wan Taib
title Effects of Leptin gene variants on obesity and its attributes in Malay population
title_short Effects of Leptin gene variants on obesity and its attributes in Malay population
title_full Effects of Leptin gene variants on obesity and its attributes in Malay population
title_fullStr Effects of Leptin gene variants on obesity and its attributes in Malay population
title_full_unstemmed Effects of Leptin gene variants on obesity and its attributes in Malay population
title_sort effects of leptin gene variants on obesity and its attributes in malay population
publishDate 2018
url http://eprints.unisza.edu.my/5610/1/FH02-FSK-19-28410-1.pdf
http://eprints.unisza.edu.my/5610/
_version_ 1725976973359972352
score 13.211869

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