Effects of Leptin gene variants on obesity and its attributes in Malay population
Leptin is a hormone that regulates the energy intake and expenditure which is encoded by leptin gene. Leptin gene variants were studied comprehensively in relation with body weight status, but the evidences were indecisive. This study was to determine the association between leptin gene variants,...
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| Format: | Article |
| Language: | English |
| Published: |
2018
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| Subjects: | |
| Online Access: | http://eprints.unisza.edu.my/5610/1/FH02-FSK-19-28410-1.pdf http://eprints.unisza.edu.my/5610/ |
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| Summary: | Leptin is a hormone that regulates the energy intake and expenditure which is
encoded by leptin gene. Leptin gene variants were studied comprehensively in
relation with body weight status, but the evidences were indecisive. This study was
to determine the association between leptin gene variants, G2548A, H1328080
and A19G with obesity and its attributes in Terengganu, Malaysian population. This
study involved a total of 249 Malay subjects (101 healthy adults with normal BMI
as the control group and 148 overweight and obese subjects). The anthropometrics
data were obtained, blood samples were collected for genetic markers and lipid
profile analyses. PCR-RFLP technique was performed to determine the genotype
and allele distribution of leptin gene variants. The genotypic and allelic frequencies
of leptin gene variants presented no significant difference between groups, G2548A
(P = 0.93 and 0.74); H1328080 (P = 0.58 and 0.56); and A19G (P = 0.72 and 0.38)
correspondingly. However, there was statistical significant difference between
triglyceride level and genotypes of G2548A variant (P = 0.016); between total
cholesterol level and H1328080 genotypes (P = 0.027). In addition, multivariate
logistic regression projected the male gender (adjusted OR= 26.27; CI= 1.06-1.25;
P = 0.009), waist circumference (adjusted OR = 1.15; CI = 1.06-1.25; P = 0.001)
and body fat percentage (adjusted OR = 1.43; CI = 1.20-1.70; P<0.001) were the
independent risk factors for obesity. The data suggest G2548A, H1328080 and
A19G variants were not associated with obesity. However, waist circumference
and body fat percentage may increase risk for obesity in Malay population. |
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