Levels of malondialdehyde-related immune reactants in a lupus prone mouse strain
The levels of malondialdehyde (MDA)-specific antibodies in lupus-prone MRL/ lpr mice of different ages were compared to those against DNA. These mice elicited anti-MDA antibodies earlier and in higher levels that anti-DNA antibodies. The levels of immune complexes containing MDA adducts were also hi...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Published: |
Universiti Kebangsaan Malaysia
1996
|
| Online Access: | http://journalarticle.ukm.my/3681/ http://www.ukm.my/jsm/english_journals/vol25num1_1996/vol25num1_96page77-86.html |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | The levels of malondialdehyde (MDA)-specific antibodies in lupus-prone MRL/ lpr mice of different ages were compared to those against DNA. These mice elicited anti-MDA antibodies earlier and in higher levels that anti-DNA antibodies. The levels of immune complexes containing MDA adducts were also higher in these mice when compared to 3 other non-lupus strains. MDA binding to a 100 kDa serum protein was observed in 3 and 5 month old mice. Immune complexes involving anti-MDA antibodies and MDA adducts may represent an additional mechanism that contributes to disease pathogenesis in these mice. |
|---|