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Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties

Microalgae are an invaluable source of new and safe therapeutics with potential antiviral and free-radical scavenging compounds. This study aimed to investigate the antiviral and antioxidant properties of local microalgae, Chlorella sp. (UKM8). The UKM8 methanol extract (UKM8-ME) was tested for anti...

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Main Authors: Abdul Fattah Shaima,, Nazlina Haiza Mohd Yasin,, Nazlina Ibrahim,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2022
Online Access:http://journalarticle.ukm.my/21704/1/ML%2014.pdf
http://journalarticle.ukm.my/21704/
https://jms.mabjournal.com/index.php/mab/index
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spelling my-ukm.journal.217042023-06-08T07:52:55Z http://journalarticle.ukm.my/21704/ Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties Abdul Fattah Shaima, Nazlina Haiza Mohd Yasin, Nazlina Ibrahim, Microalgae are an invaluable source of new and safe therapeutics with potential antiviral and free-radical scavenging compounds. This study aimed to investigate the antiviral and antioxidant properties of local microalgae, Chlorella sp. (UKM8). The UKM8 methanol extract (UKM8-ME) was tested for antiviral activity using plaque reduction assay against Human Herpes Virus type 1 (HHV-1). The antioxidant activity of UKM8-ME was evaluated for the radical scavenging activity (RSA) according to the elimination of 1,1-diphenyl-2-pikrilhydrazil (DPPH) radicals and total phenolic content (TPC) by the Folin-Ciocalteu reactions. UKM8-ME effective concentration that inhibits 50% (EC50) of plaque formation was 222.33 ± 24.54 μg/mL. The calculated selective index is 19 indicating potential antiviral activity. In the DPPH assay, the IC50 value of positive control and UKM8-ME were 122.9 ± 29.1 and 198.78 ± 14.35 μg/mL, respectively. The TPC of positive control and UKM8-ME were 263.414 ± 9.6 and 254.793 ± 3.31 mg GAE/g, respectively. Evaluation in RSA and TPC concludes that UKM8-ME has high antioxidant activity. In conclusion, UKM8-ME has two unique properties in anti-HHV-1 and antioxidant activities that can be further evaluated for potential in pharmaceutics and food ingredients. Penerbit Universiti Kebangsaan Malaysia 2022 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/21704/1/ML%2014.pdf Abdul Fattah Shaima, and Nazlina Haiza Mohd Yasin, and Nazlina Ibrahim, (2022) Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties. Malaysian Applied Biology, 51 (5). pp. 153-158. ISSN 0126-8643 https://jms.mabjournal.com/index.php/mab/index
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description Microalgae are an invaluable source of new and safe therapeutics with potential antiviral and free-radical scavenging compounds. This study aimed to investigate the antiviral and antioxidant properties of local microalgae, Chlorella sp. (UKM8). The UKM8 methanol extract (UKM8-ME) was tested for antiviral activity using plaque reduction assay against Human Herpes Virus type 1 (HHV-1). The antioxidant activity of UKM8-ME was evaluated for the radical scavenging activity (RSA) according to the elimination of 1,1-diphenyl-2-pikrilhydrazil (DPPH) radicals and total phenolic content (TPC) by the Folin-Ciocalteu reactions. UKM8-ME effective concentration that inhibits 50% (EC50) of plaque formation was 222.33 ± 24.54 μg/mL. The calculated selective index is 19 indicating potential antiviral activity. In the DPPH assay, the IC50 value of positive control and UKM8-ME were 122.9 ± 29.1 and 198.78 ± 14.35 μg/mL, respectively. The TPC of positive control and UKM8-ME were 263.414 ± 9.6 and 254.793 ± 3.31 mg GAE/g, respectively. Evaluation in RSA and TPC concludes that UKM8-ME has high antioxidant activity. In conclusion, UKM8-ME has two unique properties in anti-HHV-1 and antioxidant activities that can be further evaluated for potential in pharmaceutics and food ingredients.
format Article
author Abdul Fattah Shaima,
Nazlina Haiza Mohd Yasin,
Nazlina Ibrahim,
spellingShingle Abdul Fattah Shaima,
Nazlina Haiza Mohd Yasin,
Nazlina Ibrahim,
Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties
author_facet Abdul Fattah Shaima,
Nazlina Haiza Mohd Yasin,
Nazlina Ibrahim,
author_sort Abdul Fattah Shaima,
title Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties
title_short Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties
title_full Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties
title_fullStr Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties
title_full_unstemmed Chlorella sp. (UKM8), a local microalgae isolate with anti-human herpes virus and antioxidant properties
title_sort chlorella sp. (ukm8), a local microalgae isolate with anti-human herpes virus and antioxidant properties
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2022
url http://journalarticle.ukm.my/21704/1/ML%2014.pdf
http://journalarticle.ukm.my/21704/
https://jms.mabjournal.com/index.php/mab/index
_version_ 1769843480328142848
score 13.211869

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