The changes of aortic stiffness during normal menstrual cycle
Pulse wave velocity (PWV), augmentation index (AI) and finger photoplethysmography fitness index (PPGF) are non-invasive markers of vascular function and may predict future cardiovascular disease (CVD) risk. In women, the changes from both oestrogen and progesterone levels during menstrual cycle...
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Pusat Perubatan Universiti Kebangsaan Malaysia
2018
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| Online Access: | http://journalarticle.ukm.my/20205/1/12_ms0180_pdf_14154.pdf http://journalarticle.ukm.my/20205/ https://www.medicineandhealthukm.com/toc/13/1 |
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my-ukm.journal.202052022-10-21T08:22:43Z http://journalarticle.ukm.my/20205/ The changes of aortic stiffness during normal menstrual cycle Amilia Aminuddin, Luqman Hakim AZ, Chan, SY Nur Elyatulnadia S, Hamizatul Akma H, Nur Shahira Afifa R, Ugusman A, Chellappan C, Pulse wave velocity (PWV), augmentation index (AI) and finger photoplethysmography fitness index (PPGF) are non-invasive markers of vascular function and may predict future cardiovascular disease (CVD) risk. In women, the changes from both oestrogen and progesterone levels during menstrual cycle may give significant impact on vascular function. Thus, this study was designed to investigate the variation of vascular function during follicular and luteal phase in healthy young women. Twenty-two healthy young women with regular menstrual cycle were recruited. Blood pressure (BP), body mass index (BMI), PWV, AI, PPGF, estradiol (Es) and progesterone (Prog) level were measured during follicular (F) and mid-luteal (L) phase. Data was analyzed via SPSS version 20 and P value < 0.05 was considered to be significant. The mean age of the subjects was 22.73 ± 0.60 years. There was significant variations of estradiol and progesterone levels during menstrual cycle whereby the level of estradiol (EsF = 107.6 ± 52.56 pmol/L vs. EsL = 555.16 ± 152.79 pmol/L, P<0.05) and progesterone (ProgF = 0.62 ± 0.26 nmol/L vs. ProgL = 46.74 ± 14.59 nmol/L, P<0.05) were higher in mid-luteal compared to follicular phase. PWV value was higher during follicular phase when compared to mid-luteal phase (PWVF = 6.67 ± 0.66 m/s vs. PWVL = 6.31 ± 0.52 m/s, P=0.01). The levels of BP, BMI, PPGF (PPGFF = 55.43 ± 7.50% vs. PPGFL = 56.59 ± 7.23 %, P=0.41) and AI (AIF = 12.87 ± 5.13% vs. AIL = 10.80 ± 4.52%, P=0.11) were unchanged between the two phases. In conclusion, PWV differs between follicular and mid-luteal phases of menstrual cycle in healthy young women. Thus, history of menstrual cycle must be taken into account when assessing PWV among women. Pusat Perubatan Universiti Kebangsaan Malaysia 2018 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/20205/1/12_ms0180_pdf_14154.pdf Amilia Aminuddin, and Luqman Hakim AZ, and Chan, SY and Nur Elyatulnadia S, and Hamizatul Akma H, and Nur Shahira Afifa R, and Ugusman A, and Chellappan C, (2018) The changes of aortic stiffness during normal menstrual cycle. Medicine & Health, 13 (1). pp. 117-129. ISSN 2289-5728 https://www.medicineandhealthukm.com/toc/13/1 |
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| description |
Pulse wave velocity (PWV), augmentation index (AI) and finger
photoplethysmography fitness index (PPGF) are non-invasive markers of vascular
function and may predict future cardiovascular disease (CVD) risk. In women,
the changes from both oestrogen and progesterone levels during menstrual cycle
may give significant impact on vascular function. Thus, this study was designed to
investigate the variation of vascular function during follicular and luteal phase in
healthy young women. Twenty-two healthy young women with regular menstrual
cycle were recruited. Blood pressure (BP), body mass index (BMI), PWV, AI, PPGF,
estradiol (Es) and progesterone (Prog) level were measured during follicular (F) and
mid-luteal (L) phase. Data was analyzed via SPSS version 20 and P value < 0.05
was considered to be significant. The mean age of the subjects was 22.73 ± 0.60
years. There was significant variations of estradiol and progesterone levels during
menstrual cycle whereby the level of estradiol (EsF = 107.6 ± 52.56 pmol/L vs. EsL
= 555.16 ± 152.79 pmol/L, P<0.05) and progesterone (ProgF = 0.62 ± 0.26 nmol/L
vs. ProgL = 46.74 ± 14.59 nmol/L, P<0.05) were higher in mid-luteal compared to
follicular phase. PWV value was higher during follicular phase when compared to
mid-luteal phase (PWVF = 6.67 ± 0.66 m/s vs. PWVL = 6.31 ± 0.52 m/s, P=0.01).
The levels of BP, BMI, PPGF (PPGFF = 55.43 ± 7.50% vs. PPGFL = 56.59 ± 7.23
%, P=0.41) and AI (AIF = 12.87 ± 5.13% vs. AIL = 10.80 ± 4.52%, P=0.11) were
unchanged between the two phases. In conclusion, PWV differs between follicular
and mid-luteal phases of menstrual cycle in healthy young women. Thus, history of
menstrual cycle must be taken into account when assessing PWV among women. |
| format |
Article |
| author |
Amilia Aminuddin, Luqman Hakim AZ, Chan, SY Nur Elyatulnadia S, Hamizatul Akma H, Nur Shahira Afifa R, Ugusman A, Chellappan C, |
| spellingShingle |
Amilia Aminuddin, Luqman Hakim AZ, Chan, SY Nur Elyatulnadia S, Hamizatul Akma H, Nur Shahira Afifa R, Ugusman A, Chellappan C, The changes of aortic stiffness during normal menstrual cycle |
| author_facet |
Amilia Aminuddin, Luqman Hakim AZ, Chan, SY Nur Elyatulnadia S, Hamizatul Akma H, Nur Shahira Afifa R, Ugusman A, Chellappan C, |
| author_sort |
Amilia Aminuddin, |
| title |
The changes of aortic stiffness during normal menstrual cycle |
| title_short |
The changes of aortic stiffness during normal menstrual cycle |
| title_full |
The changes of aortic stiffness during normal menstrual cycle |
| title_fullStr |
The changes of aortic stiffness during normal menstrual cycle |
| title_full_unstemmed |
The changes of aortic stiffness during normal menstrual cycle |
| title_sort |
changes of aortic stiffness during normal menstrual cycle |
| publisher |
Pusat Perubatan Universiti Kebangsaan Malaysia |
| publishDate |
2018 |
| url |
http://journalarticle.ukm.my/20205/1/12_ms0180_pdf_14154.pdf http://journalarticle.ukm.my/20205/ https://www.medicineandhealthukm.com/toc/13/1 |
| _version_ |
1748181781339701248 |
| score |
13.211869 |