The changes of aortic stiffness during normal menstrual cycle
Pulse wave velocity (PWV), augmentation index (AI) and finger photoplethysmography fitness index (PPGF) are non-invasive markers of vascular function and may predict future cardiovascular disease (CVD) risk. In women, the changes from both oestrogen and progesterone levels during menstrual cycle...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Perubatan Universiti Kebangsaan Malaysia
2018
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| Online Access: | http://journalarticle.ukm.my/20205/1/12_ms0180_pdf_14154.pdf http://journalarticle.ukm.my/20205/ https://www.medicineandhealthukm.com/toc/13/1 |
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| Summary: | Pulse wave velocity (PWV), augmentation index (AI) and finger
photoplethysmography fitness index (PPGF) are non-invasive markers of vascular
function and may predict future cardiovascular disease (CVD) risk. In women,
the changes from both oestrogen and progesterone levels during menstrual cycle
may give significant impact on vascular function. Thus, this study was designed to
investigate the variation of vascular function during follicular and luteal phase in
healthy young women. Twenty-two healthy young women with regular menstrual
cycle were recruited. Blood pressure (BP), body mass index (BMI), PWV, AI, PPGF,
estradiol (Es) and progesterone (Prog) level were measured during follicular (F) and
mid-luteal (L) phase. Data was analyzed via SPSS version 20 and P value < 0.05
was considered to be significant. The mean age of the subjects was 22.73 ± 0.60
years. There was significant variations of estradiol and progesterone levels during
menstrual cycle whereby the level of estradiol (EsF = 107.6 ± 52.56 pmol/L vs. EsL
= 555.16 ± 152.79 pmol/L, P<0.05) and progesterone (ProgF = 0.62 ± 0.26 nmol/L
vs. ProgL = 46.74 ± 14.59 nmol/L, P<0.05) were higher in mid-luteal compared to
follicular phase. PWV value was higher during follicular phase when compared to
mid-luteal phase (PWVF = 6.67 ± 0.66 m/s vs. PWVL = 6.31 ± 0.52 m/s, P=0.01).
The levels of BP, BMI, PPGF (PPGFF = 55.43 ± 7.50% vs. PPGFL = 56.59 ± 7.23
%, P=0.41) and AI (AIF = 12.87 ± 5.13% vs. AIL = 10.80 ± 4.52%, P=0.11) were
unchanged between the two phases. In conclusion, PWV differs between follicular
and mid-luteal phases of menstrual cycle in healthy young women. Thus, history of
menstrual cycle must be taken into account when assessing PWV among women. |
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