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Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review

The separation of azole antifungal chiral compounds has gaining much interests since 1980’s as they possess different biological, pharmaceutical, and pharmacokinetic behaviors at various toxicity levels. Numerous studies have looked into this subject matter, and therefore, this review presents an...

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Main Authors: Nurul Raihana Azhari,, Boon, Yih Hui, Nur Nadhirah Mohamad Zain,, Faiz Bukhari Mohd Suah,, Sharifah Mohamad,, Noorfatimah Yahaya,, Muggundha Raoov,
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2020
Online Access:http://journalarticle.ukm.my/16000/1/9.pdf
http://journalarticle.ukm.my/16000/
https://www.ukm.my/jsm/malay_journals/jilid49bil11_2020/KandunganJilid49Bil11_2020.html
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spelling my-ukm.journal.160002020-12-17T04:53:52Z http://journalarticle.ukm.my/16000/ Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review Nurul Raihana Azhari, Boon, Yih Hui Nur Nadhirah Mohamad Zain, Faiz Bukhari Mohd Suah, Sharifah Mohamad, Noorfatimah Yahaya, Muggundha Raoov, The separation of azole antifungal chiral compounds has gaining much interests since 1980’s as they possess different biological, pharmaceutical, and pharmacokinetic behaviors at various toxicity levels. Numerous studies have looked into this subject matter, and therefore, this review presents an overview on different chiral separation techniques that have been developed such as liquid chromatography (LC), gas chromatography (GC), supercritical fluid chromatography (SFC), and capillary electrophoresis (CE). This comprehensive review also discusses the mechanisms of the developed analytical methods such as preparation techniques and optimization parameters towards the enantioseparation performances as well as their advantages and drawbacks. Lastly, the conclusion and future directions of the chiral separation, particularly for azole compounds are provided accordingly. Penerbit Universiti Kebangsaan Malaysia 2020-11 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/16000/1/9.pdf Nurul Raihana Azhari, and Boon, Yih Hui and Nur Nadhirah Mohamad Zain, and Faiz Bukhari Mohd Suah, and Sharifah Mohamad, and Noorfatimah Yahaya, and Muggundha Raoov, (2020) Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review. Sains Malaysiana, 49 (11). pp. 2699-2714. ISSN 0126-6039 https://www.ukm.my/jsm/malay_journals/jilid49bil11_2020/KandunganJilid49Bil11_2020.html
institution Universiti Kebangsaan Malaysia
building Tun Sri Lanang Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Kebangsaan Malaysia
content_source UKM Journal Article Repository
url_provider http://journalarticle.ukm.my/
language English
description The separation of azole antifungal chiral compounds has gaining much interests since 1980’s as they possess different biological, pharmaceutical, and pharmacokinetic behaviors at various toxicity levels. Numerous studies have looked into this subject matter, and therefore, this review presents an overview on different chiral separation techniques that have been developed such as liquid chromatography (LC), gas chromatography (GC), supercritical fluid chromatography (SFC), and capillary electrophoresis (CE). This comprehensive review also discusses the mechanisms of the developed analytical methods such as preparation techniques and optimization parameters towards the enantioseparation performances as well as their advantages and drawbacks. Lastly, the conclusion and future directions of the chiral separation, particularly for azole compounds are provided accordingly.
format Article
author Nurul Raihana Azhari,
Boon, Yih Hui
Nur Nadhirah Mohamad Zain,
Faiz Bukhari Mohd Suah,
Sharifah Mohamad,
Noorfatimah Yahaya,
Muggundha Raoov,
spellingShingle Nurul Raihana Azhari,
Boon, Yih Hui
Nur Nadhirah Mohamad Zain,
Faiz Bukhari Mohd Suah,
Sharifah Mohamad,
Noorfatimah Yahaya,
Muggundha Raoov,
Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review
author_facet Nurul Raihana Azhari,
Boon, Yih Hui
Nur Nadhirah Mohamad Zain,
Faiz Bukhari Mohd Suah,
Sharifah Mohamad,
Noorfatimah Yahaya,
Muggundha Raoov,
author_sort Nurul Raihana Azhari,
title Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review
title_short Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review
title_full Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review
title_fullStr Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review
title_full_unstemmed Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review
title_sort enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2020
url http://journalarticle.ukm.my/16000/1/9.pdf
http://journalarticle.ukm.my/16000/
https://www.ukm.my/jsm/malay_journals/jilid49bil11_2020/KandunganJilid49Bil11_2020.html
_version_ 1687394680851922944
score 13.211869

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