Enantiomeric separation of azole antifungal compounds using chromatographic and electrophoretic techniques: a mini review
The separation of azole antifungal chiral compounds has gaining much interests since 1980’s as they possess different biological, pharmaceutical, and pharmacokinetic behaviors at various toxicity levels. Numerous studies have looked into this subject matter, and therefore, this review presents an...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2020
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| Online Access: | http://journalarticle.ukm.my/16000/1/9.pdf http://journalarticle.ukm.my/16000/ https://www.ukm.my/jsm/malay_journals/jilid49bil11_2020/KandunganJilid49Bil11_2020.html |
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| Summary: | The separation of azole antifungal chiral compounds has gaining much interests since 1980’s as they possess different
biological, pharmaceutical, and pharmacokinetic behaviors at various toxicity levels. Numerous studies have looked
into this subject matter, and therefore, this review presents an overview on different chiral separation techniques that
have been developed such as liquid chromatography (LC), gas chromatography (GC), supercritical fluid chromatography
(SFC), and capillary electrophoresis (CE). This comprehensive review also discusses the mechanisms of the developed
analytical methods such as preparation techniques and optimization parameters towards the enantioseparation
performances as well as their advantages and drawbacks. Lastly, the conclusion and future directions of the chiral
separation, particularly for azole compounds are provided accordingly. |
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