Tuberculosis and associated factors among type 2 diabetic patients in Perak: a case control study
This is a case-control study conducted with diabetic patients in Kinta, Kampar and Larut-Matang-Selama districts of Perak, Malaysia. We intended to determine the factors contributing to the development of active tuberculosis among diabetes patients. Cases were culture-proven and registered in the...
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Penerbit Universiti Kebangsaan Malaysia
2020
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my-ukm.journal.153982020-10-23T01:00:40Z http://journalarticle.ukm.my/15398/ Tuberculosis and associated factors among type 2 diabetic patients in Perak: a case control study Kui, Choon Yong Noor Azimah Muhammad, Lim, Wei-Yin Amar-Singh HSS, This is a case-control study conducted with diabetic patients in Kinta, Kampar and Larut-Matang-Selama districts of Perak, Malaysia. We intended to determine the factors contributing to the development of active tuberculosis among diabetes patients. Cases were culture-proven and registered in the Malaysian National Tuberculosis Surveillance Registry (MyTB) from 2012 to 2018. Controls were diabetes patients identified from the National Diabetes Registry and were matched with cases based on the clinic in which they were registered at a ratio of 1:1. 119 cases and 119 controls were included in this study. Multivariate analysis was used to identify clinical factors associated with tuberculosis. Patient had increased odds of having tuberculosis if they had higher glycaemic (HbA1c) levels (OR=1.41, 95% CI 0.22-0.96, p<0.001) or nephropathy (OR=8.91, 95% CI 2.31-34.05, p<0.001). The odds ratio was lower if they have diabetes for at or more than 5 years (OR=0.46, 95% CI 0.22-0.96, p=0.04) and older (OR=0.96, CI 0.92-0.99, p=0.02). In conclusion, this study suggests that routine screening for tuberculosis in patients with diabetes should consider the diabetic duration, glycemic control, presence of nephropathy, and age of the patient. Penerbit Universiti Kebangsaan Malaysia 2020-05 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/15398/1/12.pdf Kui, Choon Yong and Noor Azimah Muhammad, and Lim, Wei-Yin and Amar-Singh HSS, (2020) Tuberculosis and associated factors among type 2 diabetic patients in Perak: a case control study. Sains Malaysiana, 49 (5). pp. 1081-1088. ISSN 0126-6039 http://www.ukm.my/jsm/malay_journals/jilid49bil5_2020/KandunganJilid49Bil5_2020.html |
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This is a case-control study conducted with diabetic patients in Kinta, Kampar and Larut-Matang-Selama districts of
Perak, Malaysia. We intended to determine the factors contributing to the development of active tuberculosis among
diabetes patients. Cases were culture-proven and registered in the Malaysian National Tuberculosis Surveillance
Registry (MyTB) from 2012 to 2018. Controls were diabetes patients identified from the National Diabetes Registry and
were matched with cases based on the clinic in which they were registered at a ratio of 1:1. 119 cases and 119 controls
were included in this study. Multivariate analysis was used to identify clinical factors associated with tuberculosis.
Patient had increased odds of having tuberculosis if they had higher glycaemic (HbA1c) levels (OR=1.41, 95% CI
0.22-0.96, p<0.001) or nephropathy (OR=8.91, 95% CI 2.31-34.05, p<0.001). The odds ratio was lower if they have
diabetes for at or more than 5 years (OR=0.46, 95% CI 0.22-0.96, p=0.04) and older (OR=0.96, CI 0.92-0.99, p=0.02).
In conclusion, this study suggests that routine screening for tuberculosis in patients with diabetes should consider the
diabetic duration, glycemic control, presence of nephropathy, and age of the patient. |
| format |
Article |
| author |
Kui, Choon Yong Noor Azimah Muhammad, Lim, Wei-Yin Amar-Singh HSS, |
| spellingShingle |
Kui, Choon Yong Noor Azimah Muhammad, Lim, Wei-Yin Amar-Singh HSS, Tuberculosis and associated factors among type 2 diabetic patients in Perak: a case control study |
| author_facet |
Kui, Choon Yong Noor Azimah Muhammad, Lim, Wei-Yin Amar-Singh HSS, |
| author_sort |
Kui, Choon Yong |
| title |
Tuberculosis and associated factors among type 2 diabetic patients in Perak: a
case control study |
| title_short |
Tuberculosis and associated factors among type 2 diabetic patients in Perak: a
case control study |
| title_full |
Tuberculosis and associated factors among type 2 diabetic patients in Perak: a
case control study |
| title_fullStr |
Tuberculosis and associated factors among type 2 diabetic patients in Perak: a
case control study |
| title_full_unstemmed |
Tuberculosis and associated factors among type 2 diabetic patients in Perak: a
case control study |
| title_sort |
tuberculosis and associated factors among type 2 diabetic patients in perak: a
case control study |
| publisher |
Penerbit Universiti Kebangsaan Malaysia |
| publishDate |
2020 |
| url |
http://journalarticle.ukm.my/15398/1/12.pdf http://journalarticle.ukm.my/15398/ http://www.ukm.my/jsm/malay_journals/jilid49bil5_2020/KandunganJilid49Bil5_2020.html |
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1681490389295431680 |
| score |
13.211869 |