Tuberculosis and associated factors among type 2 diabetic patients in Perak: a case control study
This is a case-control study conducted with diabetic patients in Kinta, Kampar and Larut-Matang-Selama districts of Perak, Malaysia. We intended to determine the factors contributing to the development of active tuberculosis among diabetes patients. Cases were culture-proven and registered in the...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penerbit Universiti Kebangsaan Malaysia
2020
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| Online Access: | http://journalarticle.ukm.my/15398/1/12.pdf http://journalarticle.ukm.my/15398/ http://www.ukm.my/jsm/malay_journals/jilid49bil5_2020/KandunganJilid49Bil5_2020.html |
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| Summary: | This is a case-control study conducted with diabetic patients in Kinta, Kampar and Larut-Matang-Selama districts of
Perak, Malaysia. We intended to determine the factors contributing to the development of active tuberculosis among
diabetes patients. Cases were culture-proven and registered in the Malaysian National Tuberculosis Surveillance
Registry (MyTB) from 2012 to 2018. Controls were diabetes patients identified from the National Diabetes Registry and
were matched with cases based on the clinic in which they were registered at a ratio of 1:1. 119 cases and 119 controls
were included in this study. Multivariate analysis was used to identify clinical factors associated with tuberculosis.
Patient had increased odds of having tuberculosis if they had higher glycaemic (HbA1c) levels (OR=1.41, 95% CI
0.22-0.96, p<0.001) or nephropathy (OR=8.91, 95% CI 2.31-34.05, p<0.001). The odds ratio was lower if they have
diabetes for at or more than 5 years (OR=0.46, 95% CI 0.22-0.96, p=0.04) and older (OR=0.96, CI 0.92-0.99, p=0.02).
In conclusion, this study suggests that routine screening for tuberculosis in patients with diabetes should consider the
diabetic duration, glycemic control, presence of nephropathy, and age of the patient. |
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