Modelling lipid biosynthesis pathways of oil palm by boolean and graphical approaches
The mathematical modelling provides an alternative way for the interpretation and prediction of cellular metabolisms. This study delves into the modelling of lipid biosynthesis pathway and the primary metabolism in the fruit of the oil palm (Elaeis guineensis). Two different data are used for th...
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| Main Authors: | , , , |
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| Format: | Book Section |
| Language: | English |
| Published: |
IEEE
2011
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| Subjects: | |
| Online Access: | http://eprints.intimal.edu.my/190/1/12.pdf http://eprints.intimal.edu.my/190/ |
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| Summary: | The mathematical modelling provides an alternative
way for the interpretation and prediction of cellular metabolisms.
This study delves into the modelling of lipid biosynthesis
pathway and the primary metabolism in the fruit of the oil
palm (Elaeis guineensis). Two different data are used for the
analysis. In the first dataset, the distribution of carbon flux
into the major classes of lipids, i.e., triacylglycerols, diacylglycerols,
monoacylglycerols, phospholipids, and free fatty
acids, is investigated using radioactive isotope. Then, the
model of carbon flux is constructed based on the Boolean
approach. On the other hand in the second dataset, the graphical
methods are implemented to construct a model for the
lipid contents of the developing oil palm mesocarp based on
the major lipid metabolites of this system as listed previously.
Moreover, the generated models are analysed for the control
structure depending on the relative ranking of degree for each
lipid class in the pathway. The results demonstrate the ability
of the models to predict the site of control in this biosynthetic
system. Furthermore, the analyses of the networks of lipids
do not only reveal underlying interactions between the major
classes of lipids but also the response of these networks towards
changing environments. |
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