Contribution of BCR-ABL Kinase Domain Mutations to Imatinib Mesylate Resistance in Philadelphia Chromosome Positive Malaysian Chronic Myeloid Leukemia Patients

Development of resistance to imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients is mediated by different mechanisms that can be classified as BCR-ABL dependent or BCR-ABL independent pathways. BCR-ABL dependent mechanisms are most frequently associated with point mutations in tyrosine...

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Bibliographic Details

Main Authors:	Marjanu Hikmah Elias, Abdul Aziz Baba, Azlan Husin, Abu Dzarr Abdullah, Rosline Hassan, Goh Ai Sim, S Fadilah Abdul Wahid, Ravindran Ankathil
Format:	Article
Language:	en
Published:	National Center for Biotechnology Information, U.S. National Library of Medicine 2024
Subjects:	BCR-ABL dependent mechanisms; chronic myeloid leukemia; imatinib mesylate; mutation; tyrosine kinase domain
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