Increased basal oxidation of peroxiredoxin 2 and limited peroxiredoxin recycling in glucose-6-phosphate dehydrogenase-deficient erythrocytes from newborn infants

Erythrocytes require glucose-6-phosphate dehydrogenase (G6PD) to generate NADPH and protect themselves against hemolytic anemia induced by oxidative stress. Peroxiredoxin 2 (Prx2) is a major antioxidant enzyme that requires NADPH to recycle its oxidized (disulfide-bonded) form. Our aims were to dete...

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Bibliographic Details

Main Authors:	Cheah, FC, Peskin, AV, Wong, FL, Ithnin, A, Othman, A, Winterbourn, CC
Format:	Article
Language:	English en_US
Published:	Federation Amer Soc Exp Biol 2024
Subjects:	antioxidant defense hydrogen peroxide hemolytic anemia
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