Design, synthesis and docking studies of Flavokawain B type chalcones and their cytotoxic effects on MCF-7 and MDA-MB-231 cell lines

Flavokawain B (1) is a natural chalcone extracted from the roots of Piper methysticum, and has been proven to be a potential cytotoxic compound. Using the partial structure of flavokawain B (FKB), about 23 analogs have been synthesized. Among them, compounds 8, 13 and 23 were found in new FKB deriva...

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Main Authors:	Abu Bakar, Addila, Akhtar, Muhammad Nadeem, Mohd Ali, Norlaily, Yeap, Swee Keong, Quah, Ching Kheng, Loh, Wan-Sin, Mohammed Alitheen, Noorjahan Banu, Zareen, Seema, Ul-Haq, Zaheer, Shah, Syed Adnan Ali
Format:	Article
Language:	en
Published:	Multidisciplinary Digital Publishing Institute 2018
Online Access:	http://psasir.upm.edu.my/id/eprint/72197/1/Design%2C%20synthesis%20and%20docking%20studies%20.pdf http://psasir.upm.edu.my/id/eprint/72197/ https://www.mdpi.com/1420-3049/23/3/616
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