Crude extracts, flavokawain B and alpinetin compounds from the rhizome of Alpinia mutica induce cell death via UCK2 enzyme inhibition and in turn reduce 18S rRNA biosynthesis in HT-29 cells

Uridine-cytidine kinase 2 is an enzyme that is overexpressed in abnormal cell growth and its implication is considered a hallmark of cancer. Due to the selective expression of UCK2 in cancer cells, a selective inhibition of this key enzyme necessitates the discovery of its potential inhibitors for c...

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Main Authors:	Malami, Ibrahim, Abdul, Ahmad Bustamam, Abdullah, Rasedee @ Mat, Kassim, Nur Kartinee, Rosli, Rozita, Yeap, Swee Keong, Waziri, Peter Maitalata, Etti, Imaobong Christopher, Bello, Muhammad Bashir
Format:	Article
Language:	en
Published:	Public Library of Science 2017
Online Access:	http://psasir.upm.edu.my/id/eprint/61259/1/Crude%20extracts%2C%20flavokawain%20B%20and%20alpinetin%20compounds%20from%20the%20rhizome%20of%20Alpinia%20mutica%20induce%20cell%20death%20via%20UCK2%20enzyme%20inhibition%20and%20in%20turn%20reduce%2018S%20rRNA%20biosynthesis%20in%20HT-29%20cells.pdf http://psasir.upm.edu.my/id/eprint/61259/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245823/pdf/pone.0170233.pdf
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