Dual redox effects of 2,6-bis-(4-hydroxyl-3-methoxybenzylidene) cyclohexanone (BHMC) on human liver cancer cells, HepG2 via ROS, glutathione and Nrf2/Keap1 pathway

Dual redox effects of 2,6-bis-(4-hydroxyl-3-methoxybenzylidene) cyclohexanone (BHMC) on human liver cancer cells, HepG2 via ROS, glutathione and Nrf2/Keap1 pathway

Introduction: Curcumin has demonstrated significant potential as a chemoprotective agent by inducing death in malignant cells while exhibiting selective cytotoxicity toward normal cells. However, curcumin has limited bioavailability which hindered its full potential. Thus, 2,6-bis-(4-hydroxyl-3-meth...

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Bibliographic Details
Main Authors: Mohd Shafiee, Muhammad Aminuddin, Syed Alwi, Sharifah Sakinah, Othman, Zulkefley, Nurdin, Armania, Md Razip, Nurliyana Najwa
Format: Article
Language:en
Published: Nature Research 2025
Subjects:
Multidisciplinary
Online Access:http://psasir.upm.edu.my/id/eprint/124392/1/124392.pdf
http://psasir.upm.edu.my/id/eprint/124392/
https://www.nature.com/articles/s41598-025-19874-y?error=cookies_not_supported&code=0a2709f3-a3e7-49b0-8dd0-b2f4bb43b606
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http://psasir.upm.edu.my/id/eprint/124392/1/124392.pdf
http://psasir.upm.edu.my/id/eprint/124392/
https://www.nature.com/articles/s41598-025-19874-y?error=cookies_not_supported&code=0a2709f3-a3e7-49b0-8dd0-b2f4bb43b606

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