Coupling of both a transactivation module and a double-stranded DNA-binding domain boosts Cas12i3 variant-based cytosine and adenine editing in plants

CRISPR/Cas12i3 belongs to the type V-I Cas system, characterized by its smaller protein size and less restricted canonical “TTN” protospacer adjacent motif. Developments of Cas12i3-mediated base editing systems for either C-to-T or A-to-G transitions will expand the editing scope and enrich the plan...

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Bibliographic Details

Main Authors:	Zhang, Chen, Li, Jingying, Li, Yucai, Yan, Lei, Yong, Christina Seok Yien, Li, Shaoya, He, Yubing, Xia, Lanqin
Format:	Article
Language:	en
Published:	John Wiley and Sons 2026
Subjects:	Biochemistry Biochemistry, Genetics and Molecular Biology (all)
Online Access:	http://psasir.upm.edu.my/id/eprint/123455/1/123455.pdf http://psasir.upm.edu.my/id/eprint/123455/ https://onlinelibrary.wiley.com/doi/10.1111/jipb.70154
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