Rationale, design and baseline characteristics of participants in the OCEANIC-STROKE trial of FXIa inhibition for secondary stroke prevention

INTRODUCTION: Genetic deficiency of factor XI is associated with a reduced risk of ischemic stroke. Asundexian is a direct inhibitor of activated factor XIa (FXIa) with a low risk of bleeding in early trials. We seek to determine its efficacy and safety combined with antiplatelet therapy for prevent...

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Main Authors:	Sharma, Mukul, Dong, Qiang, Hirano, Teruyuki, Kasner, Scott E., Saver, Jeffrey, Masjuan, Jaime, Demchuk, Andrew M., Cordonnier, Charlotte, Bereczki, Daniel, Tsivgoulis, Georgios, Veltkamp, Roland, Staikov, Ivan, Bae, Hee Joon, Campbell, Bruce C.V., Zini, Andrea, Lee, I. Hui, Ameriso, Sebastian, Kovar, Martin, Mikulik, Robert, Lemmens, Robin, Ferro, José M., Robinson, Thompson, Christensen, Hanne, Ozturk, Serefnur, Leker, Ronen R., Turcani, Peter, Slowik, Agnieszka, Amaya, Pablo, Hoo, Fan Kee, De Marchis, Gian Marco, Knoflach, Michael, Sylaja, Pillai N., Putaala, Jukka, Coutinho, Jonathan M., Worp, H. Bart van der, Miglane, Evija, Matijosaitis, Vaidas, Lindgren, Arne G., Silva, Gisele Sampaio, Sandset, Else Charlotte, Turuspekova, Saule Tleubergenovna, Joundi, Raed A., Schulze, Karleen, Shestakovska, Olga, Gilbride, Jennifer, Bangdiwala, Shrikant I., Xu, Lizhen, Muehlhofer, Eva, Colorado, Pablo, Mundl, Hardi, Keller, Lars, Shoamanesh, Ashkan
Format:	Article
Language:	en
Published:	Oxford University Press 2026
Subjects:	Neurology (clinical) Cardiology and Cardiovascular Medicine
Online Access:	http://psasir.upm.edu.my/id/eprint/123407/1/123407.pdf http://psasir.upm.edu.my/id/eprint/123407/ https://academic.oup.com/esj/article/doi/10.1093/esj/aakaf017/8407782
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