A Japanese encephalitis virus biological clone with an E gene point mutation exhibits in vitro and in vivo attenuation of neurovirulence

The Japanese encephalitis virus (JEV), a leading cause of viral encephalitis, exists as similar but non-identical biological clones whose genomic variations/mutations may determine neurovirulence. Two biological clones purified from a brain-derived, clinical isolate were tested in vitro for neurovir...

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Bibliographic Details
Main Authors: Shu, Pin Yu, Kien, Chai Ong, Soon, Hao Tan, Tomohiro, Ishikawa, David, Perera, Yuan, Teng Hooi, Wong, Kum Thong
Format: Article
Language:en
Published: Microbiology Society 2025
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Online Access:http://ir.unimas.my/id/eprint/49410/3/A%20Japanese.pdf
http://ir.unimas.my/id/eprint/49410/
https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.002137
https://doi.org/10.1099/jgv.0.002137
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