Substitution of Coxsackievirus A16 VP1 BC and EF Loop Altered the Protective Immune Responses in Chimera Enterovirus A71

Hand, foot and mouth disease (HFMD) is a childhood disease caused by enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16). Capsid loops are important epitopes for EV-A71 and CV-A16. Seven chimeric EV-A71 (ChiE71) involving VP1 BC (45.5% similarity), DE, EF, GH and HI loops, VP2 EF loop and VP3 G...

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Main Authors:	Xiu Hui, Tan, Wei Lim, Chong, Vannajan Sanghiran, Lee, Syahril, Abdullah, Kartini, Jasni, Saiful Qushairi, Suarni, David, Perera, I Ching, Sam, Yoke Fun, Chan
Format:	Article
Language:	en
Published:	MDPI 2023
Subjects:	Q Science (General) QR355 Virology R Medicine (General)
Online Access:	http://ir.unimas.my/id/eprint/43593/3/Substitution.pdf http://ir.unimas.my/id/eprint/43593/ https://www.mdpi.com/2076-393X/11/8/1363 https://doi.org/10.3390/vaccines11081363
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