IMiD/CELMoD-induced growth suppression of adult T-cell leukemia/lymphoma cells via cereblon through downregulation of target proteins and their downstream effectors

Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasia associated with human T-cell leukemia virus type 1 (HTLV-1) infection and has an extremely poor prognosis. Lenalidomide (LEN; a second-generation immunomodulatory drug [IMiD]) has been employed as an additional therapeutic option...

Full description

Bibliographic Details

Main Authors:	Yu Wang, Shunsuke Shimosaki, Emi Ikebe, Hidekatsu Iha, Jun-ichi Yamamoto, Nichole Fife, Tomonaga Ichikawa, Mitsuo Hori, Masao Ogata, Yoshiyuki Tsukamoto, Naoki Hijiya, Masatsugu Moriyama, Shotaro Hagiwara, Shuichi Kusano, Masumichi Saito, Kamruddin Ahmed, Akira Nishizono, Hiroshi Handa, Kazuhiro Morishita
Format:	Article
Language:	en en
Published:	Frontiers Media SA 2024
Subjects:	R5-920 Medicine (General) RC254-282 Neoplasms. Tumors. Oncology Including cancer and carcinogens RC633-647.5 Diseases of the blood and blood-forming organs
Online Access:	https://eprints.ums.edu.my/id/eprint/38798/1/ABSTRACT.pdf https://eprints.ums.edu.my/id/eprint/38798/2/FULL%20TEXT.pdf https://eprints.ums.edu.my/id/eprint/38798/ https://doi.org/10.3389/fonc.2023.1272528
Tags:	Add Tag No Tags, Be the first to tag this record!