Sustainable Syntheses of (−)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site

The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-Targeting agents with broad spectrum anticancer activity. The natural supply of these precious metabolites has been significantly disrupted due to the inclusion of T. corymbosa on the endang...

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Main Authors:	Smedley, C.J., Stanley, P.A., Qazzaz, M.E., Prota, A.E., Olieric, N., Collins, H., Eastman, H., Barrow, A.S., Lim, K.H., Kam, T.S., Smith, B.J., Duivenvoorden, H.M., Parker, B.S., Bradshaw, T.D., Steinmetz, M.O., Moses, J.E.
Format:	Article
Language:	en
Published:	Nature Publishing Group 2018
Subjects:	Q Science (General) R Medicine
Online Access:	http://eprints.um.edu.my/18983/1/Sustainable_Syntheses_of_%28-%29-Jerantinines_A_%26_e_and_Structural_Characterisation_of_the_Jerantinine-Tubulin_Complex_at_the_Colchicine_Binding_Site.pdf http://eprints.um.edu.my/18983/ http://dx.doi.org/10.1038/s41598-018-28880-2
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