Runx1 Deficiency in CD4+ T Cells Causes Fatal Autoimmune Inflammatory Lung Disease Due to Spontaneous Hyperactivation of Cells

The Runx1 transcription factor is abundantly expressed in naive T cells but rapidly downregulated in activated T cells, suggesting that it plays an important role in a naive stage. In the current study, Runx1−/−Bcl2tg mice harboring Runx1-deleted CD4+ T cells developed a fatal autoimmune lung diseas...

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Main Authors:	Wong, W.F., Kohu, K., Nakamura, A., Ebina, M., Kikuchi, T., Tazawa, R., Tanaka, K., Kon, S., Funaki, T., Sugahara-Tobinai, A., Looi, C.Y., Endo, S., Funayama, R., Kurokawa, M., Habu, S., Ishii, N., Fukumoto, M., Nakata, K., Takai, T., Satake, M.
Format:	Article
Published:	American Association of Immunologists 2012
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/13026/ http://www.jimmunol.org/content/188/11/5408.long http://dx.doi.org/10.4049/​jimmunol.1102991
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