Molecular mechanisms underlying the clinical efficacy of panobinostat involve Stochasticity of epigenetic signaling, sensitization to anticancer drugs, and induction of cellular cell death related to cellular stresses

Panobinostat, also known as Farydak®, LBH589, PNB, or panobinostat lactate, is a hydroxamic acid that has been approved by the Food and Drug Administration (FDA) for its anti-cancer properties. This orally bioavailable drug is classified as a non-selective histone deacetylase inhibitor (pan-HDACi) t...

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Main Authors:	El Omari, Nasreddine, Bakrim, Saad, Khalid, Asaad, Abdalla, Ashraf N., Almalki, Waleed Hassan, Lee, Learn-Han, Ardianto, Chrismawan, Long, Chiau Ming *, Bouyahya, Abdelhakim
Format:	Article
Language:	en
Published:	Elsevier 2023
Subjects:	QH Natural history RC Internal medicine
Online Access:	http://eprints.sunway.edu.my/2711/1/Long%20Chiau%20Ming_Molecular%20mechanisms%20underlying%20the%20clinical%20efficacy%20of%20panobinostat.pdf http://eprints.sunway.edu.my/2711/ https://doi.org/10.1016/j.biopha.2023.114886
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