Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones: synthesis, biological activity, crystal structure analysis, and molecular docking studies

In search of potent anti-inflammatory agents, twenty-four chalcone derivatives including seven new compounds (13 – 17, 21 and 23) containing pyrrole moiety were designed, synthesized, and assessed for their nitric oxide (NO) and prostaglandin E2 (PGE2) suppression ability on IFN-γ/LPS-induced RAW 26...

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Main Authors:	Mohd Faudzi, Siti Munirah, Abdullah, Maryam Aisyah, Abdull Manap, Mohd Rashidi, Ismail, Ahmad Zaidi, Rullah, Kamal, Mohd Aluwi, Mohd Fadhlizil Fasihi, Mazila Ramli, Aizi Nor, Abas, Faridah, Lajis, Nordin H.
Format:	Article
Language:	en en
Published:	Academic Press Inc. 2020
Subjects:	RS403 Materia Medica-Pharmaceutical Chemistry
Online Access:	http://irep.iium.edu.my/77065/14/Scopus%20-%20Inhibition%20of%20nitric%20oxide%20and%20prostaglandin.pdf http://irep.iium.edu.my/77065/25/77065_Inhibition%20of%20nitric%20oxide%20and%20prostaglandin%20E2%20production.pdf http://irep.iium.edu.my/77065/ https://www.sciencedirect.com/science/article/pii/S0045206819315214
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