CDK9 inhibitors define elongation checkpoints at both ends of RNA polymerase II-transcribed genes

Transcription through early-elongation checkpoints requires phosphorylation of negative transcription elongation factors (NTEFs) by the cyclin-dependent kinase (CDK)9. Using CDK9 inhibitors and global run-on sequencing (GRO-seq), we have mapped CDK9 inhibitor-sensitive checkpoints genome-wide in...

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Bibliographic Details

Main Authors:	Laitem, Clélia, Zaborowska, Justyna, Isa, Nur Firdaus, Kufs, Johann, Dienstbier, Martin, Murphy, Shona
Format:	Article
Language:	en en
Published:	Nature Publishing Group 2015
Subjects:	Q Science (General) R Medicine (General)
Online Access:	http://irep.iium.edu.my/60432/1/2015-NSMB.pdf http://irep.iium.edu.my/60432/7/60432_CDK9%20inhibitors%20define%20elongation_scopus.pdf http://irep.iium.edu.my/60432/ https://www.nature.com/articles/nsmb.3000
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