Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for screening antifungal exposure in intensive care units— the SAFE‑ICU study

Purpose Appropriate antifungal therapy is a major determinant of survival in critically ill patients with invasive fungal disease. We sought to describe whether contemporary dosing of antifungals achieves therapeutic exposures in critically ill patients. Methods In a prospective, open-label, mu...

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Bibliographic Details

Main Authors:	Roberts, Jason A., Sime, Fekade B., Lipman, Jeffrey, Hernandez‑Mitre, Maria Patricia, Baptista, Joao Pedro, Bruggemann, Roger J., Darvall, Jai, Waele, Jan J. De, Dimopoulos, George, Lefran, Jean‑Yves, Mat Nor, Mohd Basri, Rello, Jordi, Seoane, Leonardo, Slavin, Monica A., Valkonen, Miia, Venditti, Mario, Ceccarelli, Giancarlo, Wong, Wai Tat, Zeitlinger, Markus, Roger, Claire
Format:	Article
Language:	en
Published:	Springer Nature 2025
Subjects:	RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid
Online Access:	http://irep.iium.edu.my/119581/8/119581_Are%20contemporary%20antifungal%20doses%20sufficient.pdf http://irep.iium.edu.my/119581/ https://link.springer.com/article/10.1007/s00134-025-07793-5
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