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Lignin derived nanoparticle intercalation on nitrogen-doped graphene quantum dots for electrochemical sensing of cardiac biomarker

Lignin-scribed graphene (LSG) conjugated with nitrogen-doped graphene quantum dots (N-GQDs) and lignin-derived silver nanoparticles (Ag NPs) was developed through a hydrothermal process for the electrochemical sensing of Troponin I, a cardiac biomarker for Acute Myocardial Infarction (AMI). A nanoco...

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Main Authors: Vasudevan, M., Remesh, S., Perumal, V., Raja, P.B., Ibrahim, M.N.M., Gopinath, S.C.B., Lee, H.-L., Karuppanan, S., Ovinis, M., Arumugam, N., Kumar, R.S.
Format: Article
Published: Elsevier Inc. 2023
Online Access:http://scholars.utp.edu.my/id/eprint/37265/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172194275&doi=10.1016%2fj.microc.2023.109405&partnerID=40&md5=ccc32a0f5b697b8ac27c9a8045f69d24
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spelling oai:scholars.utp.edu.my:372652023-10-04T08:36:11Z http://scholars.utp.edu.my/id/eprint/37265/ Lignin derived nanoparticle intercalation on nitrogen-doped graphene quantum dots for electrochemical sensing of cardiac biomarker Vasudevan, M. Remesh, S. Perumal, V. Raja, P.B. Ibrahim, M.N.M. Gopinath, S.C.B. Lee, H.-L. Karuppanan, S. Ovinis, M. Arumugam, N. Kumar, R.S. Lignin-scribed graphene (LSG) conjugated with nitrogen-doped graphene quantum dots (N-GQDs) and lignin-derived silver nanoparticles (Ag NPs) was developed through a hydrothermal process for the electrochemical sensing of Troponin I, a cardiac biomarker for Acute Myocardial Infarction (AMI). A nanocomposite with optimal conduction mechanism was developed by varying the N-GQDs doped amount intercalated on the surface of LSG. The nanocomposite was characterised by morphological, physical, and structural examinations. The Ag NPs and N-GQDs were found uniformly distributed on the LSG surface, with selective capture of the biotinylated aptamer probe on the bio-electrode indicative of the specific interaction with Troponin I, resulting in an increment in the charge transfer resistance following hybridisation analysis. The detection limit, as determined through impedance spectroscopy, was 1 fM or 30 fg/mL, with high levels of linearity, selectivity, repeatability, and stability of the sensor. This nanocomposite opens a new avenue for array-based medical diagnostics. © 2023 Elsevier Inc. 2023 Article NonPeerReviewed Vasudevan, M. and Remesh, S. and Perumal, V. and Raja, P.B. and Ibrahim, M.N.M. and Gopinath, S.C.B. and Lee, H.-L. and Karuppanan, S. and Ovinis, M. and Arumugam, N. and Kumar, R.S. (2023) Lignin derived nanoparticle intercalation on nitrogen-doped graphene quantum dots for electrochemical sensing of cardiac biomarker. Microchemical Journal, 195. ISSN 0026265X https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172194275&doi=10.1016%2fj.microc.2023.109405&partnerID=40&md5=ccc32a0f5b697b8ac27c9a8045f69d24 10.1016/j.microc.2023.109405 10.1016/j.microc.2023.109405 10.1016/j.microc.2023.109405
institution Universiti Teknologi Petronas
building UTP Resource Centre
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Petronas
content_source UTP Institutional Repository
url_provider http://eprints.utp.edu.my/
description Lignin-scribed graphene (LSG) conjugated with nitrogen-doped graphene quantum dots (N-GQDs) and lignin-derived silver nanoparticles (Ag NPs) was developed through a hydrothermal process for the electrochemical sensing of Troponin I, a cardiac biomarker for Acute Myocardial Infarction (AMI). A nanocomposite with optimal conduction mechanism was developed by varying the N-GQDs doped amount intercalated on the surface of LSG. The nanocomposite was characterised by morphological, physical, and structural examinations. The Ag NPs and N-GQDs were found uniformly distributed on the LSG surface, with selective capture of the biotinylated aptamer probe on the bio-electrode indicative of the specific interaction with Troponin I, resulting in an increment in the charge transfer resistance following hybridisation analysis. The detection limit, as determined through impedance spectroscopy, was 1 fM or 30 fg/mL, with high levels of linearity, selectivity, repeatability, and stability of the sensor. This nanocomposite opens a new avenue for array-based medical diagnostics. © 2023
format Article
author Vasudevan, M.
Remesh, S.
Perumal, V.
Raja, P.B.
Ibrahim, M.N.M.
Gopinath, S.C.B.
Lee, H.-L.
Karuppanan, S.
Ovinis, M.
Arumugam, N.
Kumar, R.S.
spellingShingle Vasudevan, M.
Remesh, S.
Perumal, V.
Raja, P.B.
Ibrahim, M.N.M.
Gopinath, S.C.B.
Lee, H.-L.
Karuppanan, S.
Ovinis, M.
Arumugam, N.
Kumar, R.S.
Lignin derived nanoparticle intercalation on nitrogen-doped graphene quantum dots for electrochemical sensing of cardiac biomarker
author_facet Vasudevan, M.
Remesh, S.
Perumal, V.
Raja, P.B.
Ibrahim, M.N.M.
Gopinath, S.C.B.
Lee, H.-L.
Karuppanan, S.
Ovinis, M.
Arumugam, N.
Kumar, R.S.
author_sort Vasudevan, M.
title Lignin derived nanoparticle intercalation on nitrogen-doped graphene quantum dots for electrochemical sensing of cardiac biomarker
title_short Lignin derived nanoparticle intercalation on nitrogen-doped graphene quantum dots for electrochemical sensing of cardiac biomarker
title_full Lignin derived nanoparticle intercalation on nitrogen-doped graphene quantum dots for electrochemical sensing of cardiac biomarker
title_fullStr Lignin derived nanoparticle intercalation on nitrogen-doped graphene quantum dots for electrochemical sensing of cardiac biomarker
title_full_unstemmed Lignin derived nanoparticle intercalation on nitrogen-doped graphene quantum dots for electrochemical sensing of cardiac biomarker
title_sort lignin derived nanoparticle intercalation on nitrogen-doped graphene quantum dots for electrochemical sensing of cardiac biomarker
publisher Elsevier Inc.
publishDate 2023
url http://scholars.utp.edu.my/id/eprint/37265/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85172194275&doi=10.1016%2fj.microc.2023.109405&partnerID=40&md5=ccc32a0f5b697b8ac27c9a8045f69d24
_version_ 1779441356989530112
score 13.211869

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