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Natural Polymer-Based Graphene Oxide Bio-nanocomposite Hydrogel Beads: Superstructures with Advanced Potentials for Drug Delivery

The current study sought to create graphene oxide-based superstructures for gastrointestinal drug delivery. Graphene oxide has a large surface area that can be used to load anti-cancer drugs via non-covalent methods such as surface adsorption and hydrogen bonding. To enhance the bio-applicability of...

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Main Authors: Rehman, S., Madni, A., Jameel, Q.A., Usman, F., Raza, M.R., Ahmad, F., Shoukat, H., Aali, H., Shafiq, A.
Format: Article
Published: Springer Science and Business Media Deutschland GmbH 2022
Online Access:http://scholars.utp.edu.my/id/eprint/34036/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85142150207&doi=10.1208%2fs12249-022-02456-w&partnerID=40&md5=a85efc01147ff6d21e1b38f1f2757530
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spelling oai:scholars.utp.edu.my:340362022-12-28T07:54:02Z http://scholars.utp.edu.my/id/eprint/34036/ Natural Polymer-Based Graphene Oxide Bio-nanocomposite Hydrogel Beads: Superstructures with Advanced Potentials for Drug Delivery Rehman, S. Madni, A. Jameel, Q.A. Usman, F. Raza, M.R. Ahmad, F. Shoukat, H. Aali, H. Shafiq, A. The current study sought to create graphene oxide-based superstructures for gastrointestinal drug delivery. Graphene oxide has a large surface area that can be used to load anti-cancer drugs via non-covalent methods such as surface adsorption and hydrogen bonding. To enhance the bio-applicability of graphene oxide, nano-hybrids were synthesized by encapsulating the graphene oxide into calcium alginate hydrogel beads through the dripping-extrusion technique. These newly developed bio-nanocomposite hybrid hydrogel beads were evaluated in structural analysis, swelling study, drug release parameters, haemolytic assay, and antibacterial activity. Doxorubicin served as a model drug. The drug entrapment efficiency was determined by UV-spectroscopy analysis and was found to be high at �89 in graphene oxide hybrid hydrogel beads. These fabricated hydrogel beads ensure the drug release from a hybrid polymeric matrix in a more controlled and sustained pattern avoiding the problems associated with a non-hybrid polymeric system. The drug release study of 12 h shows about 83 release at pH 6.8. In vitro drug release kinetics proved that drug release was a Fickian mechanism. The cytotoxic effect of graphene oxide hybrid alginate beads was also determined by evaluating the morphology of bacterial cells and red blood cells after incubation. Additionally, it was determined that the sequential encapsulation of graphene oxide in alginate hydrogel beads hides its uneven edges and lessens the graphene oxide�s negative impacts. Also, the antibacterial study and biocompatibility of fabricated hydrogel beads made them potential candidates for gastrointestinal delivery. Graphical Abstract: Figure not available: see fulltext. © 2022, The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists. Springer Science and Business Media Deutschland GmbH 2022 Article NonPeerReviewed Rehman, S. and Madni, A. and Jameel, Q.A. and Usman, F. and Raza, M.R. and Ahmad, F. and Shoukat, H. and Aali, H. and Shafiq, A. (2022) Natural Polymer-Based Graphene Oxide Bio-nanocomposite Hydrogel Beads: Superstructures with Advanced Potentials for Drug Delivery. AAPS PharmSciTech, 23 (8). ISSN 15309932 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85142150207&doi=10.1208%2fs12249-022-02456-w&partnerID=40&md5=a85efc01147ff6d21e1b38f1f2757530 10.1208/s12249-022-02456-w 10.1208/s12249-022-02456-w 10.1208/s12249-022-02456-w
institution Universiti Teknologi Petronas
building UTP Resource Centre
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Petronas
content_source UTP Institutional Repository
url_provider http://eprints.utp.edu.my/
description The current study sought to create graphene oxide-based superstructures for gastrointestinal drug delivery. Graphene oxide has a large surface area that can be used to load anti-cancer drugs via non-covalent methods such as surface adsorption and hydrogen bonding. To enhance the bio-applicability of graphene oxide, nano-hybrids were synthesized by encapsulating the graphene oxide into calcium alginate hydrogel beads through the dripping-extrusion technique. These newly developed bio-nanocomposite hybrid hydrogel beads were evaluated in structural analysis, swelling study, drug release parameters, haemolytic assay, and antibacterial activity. Doxorubicin served as a model drug. The drug entrapment efficiency was determined by UV-spectroscopy analysis and was found to be high at �89 in graphene oxide hybrid hydrogel beads. These fabricated hydrogel beads ensure the drug release from a hybrid polymeric matrix in a more controlled and sustained pattern avoiding the problems associated with a non-hybrid polymeric system. The drug release study of 12 h shows about 83 release at pH 6.8. In vitro drug release kinetics proved that drug release was a Fickian mechanism. The cytotoxic effect of graphene oxide hybrid alginate beads was also determined by evaluating the morphology of bacterial cells and red blood cells after incubation. Additionally, it was determined that the sequential encapsulation of graphene oxide in alginate hydrogel beads hides its uneven edges and lessens the graphene oxide�s negative impacts. Also, the antibacterial study and biocompatibility of fabricated hydrogel beads made them potential candidates for gastrointestinal delivery. Graphical Abstract: Figure not available: see fulltext. © 2022, The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.
format Article
author Rehman, S.
Madni, A.
Jameel, Q.A.
Usman, F.
Raza, M.R.
Ahmad, F.
Shoukat, H.
Aali, H.
Shafiq, A.
spellingShingle Rehman, S.
Madni, A.
Jameel, Q.A.
Usman, F.
Raza, M.R.
Ahmad, F.
Shoukat, H.
Aali, H.
Shafiq, A.
Natural Polymer-Based Graphene Oxide Bio-nanocomposite Hydrogel Beads: Superstructures with Advanced Potentials for Drug Delivery
author_facet Rehman, S.
Madni, A.
Jameel, Q.A.
Usman, F.
Raza, M.R.
Ahmad, F.
Shoukat, H.
Aali, H.
Shafiq, A.
author_sort Rehman, S.
title Natural Polymer-Based Graphene Oxide Bio-nanocomposite Hydrogel Beads: Superstructures with Advanced Potentials for Drug Delivery
title_short Natural Polymer-Based Graphene Oxide Bio-nanocomposite Hydrogel Beads: Superstructures with Advanced Potentials for Drug Delivery
title_full Natural Polymer-Based Graphene Oxide Bio-nanocomposite Hydrogel Beads: Superstructures with Advanced Potentials for Drug Delivery
title_fullStr Natural Polymer-Based Graphene Oxide Bio-nanocomposite Hydrogel Beads: Superstructures with Advanced Potentials for Drug Delivery
title_full_unstemmed Natural Polymer-Based Graphene Oxide Bio-nanocomposite Hydrogel Beads: Superstructures with Advanced Potentials for Drug Delivery
title_sort natural polymer-based graphene oxide bio-nanocomposite hydrogel beads: superstructures with advanced potentials for drug delivery
publisher Springer Science and Business Media Deutschland GmbH
publishDate 2022
url http://scholars.utp.edu.my/id/eprint/34036/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85142150207&doi=10.1208%2fs12249-022-02456-w&partnerID=40&md5=a85efc01147ff6d21e1b38f1f2757530
_version_ 1753790787131277312
score 13.211869

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