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Attention-Deficit/ Hyperactivity Disorder Brain Functional Reference: Introducing an Inter-subject Consistency Measure and Dual-layer Parcellation

The latest advancements in neuroimaging techniques have contributed to studying the disordered human brain, but still, there is a lack of disease-specific brain reference to localise brain seeds and standardise the comparison across studies. The current study first evaluates the inter-subject consis...

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Main Authors: Al-Ubaidi, Dalia Abdulhadi, Abu Samah, Azurah, Jasim, Mahdi Nsaif
Format: Article
Language:English
Published: Universiti Utara Malaysia Press 2024
Subjects:
QA Mathematics
Online Access:https://repo.uum.edu.my/id/eprint/31276/1/JICT%2023%2002%202024%20335-359.pdf
https://doi.org/10.32890/jict2024.23.2.6
https://repo.uum.edu.my/id/eprint/31276/
https://e-journal.uum.edu.my/index.php/jict/article/view/23327
https://doi.org/10.32890/jict2024.23.2.6
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spelling my.uum.repo.312762024-08-14T06:40:46Z https://repo.uum.edu.my/id/eprint/31276/ Attention-Deficit/ Hyperactivity Disorder Brain Functional Reference: Introducing an Inter-subject Consistency Measure and Dual-layer Parcellation Al-Ubaidi, Dalia Abdulhadi Abu Samah, Azurah Jasim, Mahdi Nsaif QA Mathematics The latest advancements in neuroimaging techniques have contributed to studying the disordered human brain, but still, there is a lack of disease-specific brain reference to localise brain seeds and standardise the comparison across studies. The current study first evaluates the inter-subject consistency across Attention-Deficit/ Hyperactivity Disorder (ADHD) in a publicly accessible resting-state functional magnetic resonance imaging (RS-fMRI) ADHD-200 dataset by proposing a new voxels similarity index (VSI) that integrates both inter-atlases flexibility (F`) from previous studies with proposed intersubjects stability (S`) measure to improve outcomes. Secondly, the study employs a dual-layer clustering-based parcellation strategy inspired by the resultant improved Master Atlas networks to examine the ADHD cerebral cortex. The suggested approach to enhancing the ADHD cortex parcellation uses spectral clustering for global structure identification, followed by hierarchical clustering for local refinements and granularity specification. The final connectivitydriven brain reference achieved an average homogeneity of 0.63, and the enhanced Master Atlas with (S’) achieved 0.35 homogeneity, surpassing the original Master Atlas with 0.27. This discovery implies that the final brain reference offers a more accurate and reliable framework to examine the connections and functions of the brain in individuals with ADHD Universiti Utara Malaysia Press 2024 Article PeerReviewed application/pdf en cc4_by https://repo.uum.edu.my/id/eprint/31276/1/JICT%2023%2002%202024%20335-359.pdf Al-Ubaidi, Dalia Abdulhadi and Abu Samah, Azurah and Jasim, Mahdi Nsaif (2024) Attention-Deficit/ Hyperactivity Disorder Brain Functional Reference: Introducing an Inter-subject Consistency Measure and Dual-layer Parcellation. Journal of ICT, 23 (2). pp. 335-359. ISSN 1675-414X https://e-journal.uum.edu.my/index.php/jict/article/view/23327 https://doi.org/10.32890/jict2024.23.2.6 https://doi.org/10.32890/jict2024.23.2.6
institution Universiti Utara Malaysia
building UUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Utara Malaysia
content_source UUM Institutional Repository
url_provider http://repo.uum.edu.my/
language English
topic QA Mathematics
spellingShingle QA Mathematics
Al-Ubaidi, Dalia Abdulhadi
Abu Samah, Azurah
Jasim, Mahdi Nsaif
Attention-Deficit/ Hyperactivity Disorder Brain Functional Reference: Introducing an Inter-subject Consistency Measure and Dual-layer Parcellation
description The latest advancements in neuroimaging techniques have contributed to studying the disordered human brain, but still, there is a lack of disease-specific brain reference to localise brain seeds and standardise the comparison across studies. The current study first evaluates the inter-subject consistency across Attention-Deficit/ Hyperactivity Disorder (ADHD) in a publicly accessible resting-state functional magnetic resonance imaging (RS-fMRI) ADHD-200 dataset by proposing a new voxels similarity index (VSI) that integrates both inter-atlases flexibility (F`) from previous studies with proposed intersubjects stability (S`) measure to improve outcomes. Secondly, the study employs a dual-layer clustering-based parcellation strategy inspired by the resultant improved Master Atlas networks to examine the ADHD cerebral cortex. The suggested approach to enhancing the ADHD cortex parcellation uses spectral clustering for global structure identification, followed by hierarchical clustering for local refinements and granularity specification. The final connectivitydriven brain reference achieved an average homogeneity of 0.63, and the enhanced Master Atlas with (S’) achieved 0.35 homogeneity, surpassing the original Master Atlas with 0.27. This discovery implies that the final brain reference offers a more accurate and reliable framework to examine the connections and functions of the brain in individuals with ADHD
format Article
author Al-Ubaidi, Dalia Abdulhadi
Abu Samah, Azurah
Jasim, Mahdi Nsaif
author_facet Al-Ubaidi, Dalia Abdulhadi
Abu Samah, Azurah
Jasim, Mahdi Nsaif
author_sort Al-Ubaidi, Dalia Abdulhadi
title Attention-Deficit/ Hyperactivity Disorder Brain Functional Reference: Introducing an Inter-subject Consistency Measure and Dual-layer Parcellation
title_short Attention-Deficit/ Hyperactivity Disorder Brain Functional Reference: Introducing an Inter-subject Consistency Measure and Dual-layer Parcellation
title_full Attention-Deficit/ Hyperactivity Disorder Brain Functional Reference: Introducing an Inter-subject Consistency Measure and Dual-layer Parcellation
title_fullStr Attention-Deficit/ Hyperactivity Disorder Brain Functional Reference: Introducing an Inter-subject Consistency Measure and Dual-layer Parcellation
title_full_unstemmed Attention-Deficit/ Hyperactivity Disorder Brain Functional Reference: Introducing an Inter-subject Consistency Measure and Dual-layer Parcellation
title_sort attention-deficit/ hyperactivity disorder brain functional reference: introducing an inter-subject consistency measure and dual-layer parcellation
publisher Universiti Utara Malaysia Press
publishDate 2024
url https://repo.uum.edu.my/id/eprint/31276/1/JICT%2023%2002%202024%20335-359.pdf
https://doi.org/10.32890/jict2024.23.2.6
https://repo.uum.edu.my/id/eprint/31276/
https://e-journal.uum.edu.my/index.php/jict/article/view/23327
https://doi.org/10.32890/jict2024.23.2.6
_version_ 1809150987476140032
score 13.211869

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