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Optimizing the photodynamic therapeutic effect of BODIPY-based photosensitizers against cancer and bacterial cells

The initiation and propagation of cancer is closely associated with bacterial infection, which generally requires the simultaneous usage of anticancer drugs and antibiotics. However, the adverse effects have increased too much due to the multiple use of chemodrugs. To tackle this problem, a successf...

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Main Authors: Masood, M.A., Wu, Y., Chen, Y., Yuan, H., Sher, N., Faiz, F., Yao, S., Qi, F., Khan, M.I., Ahmed, M., Mushtaq, N., He, W., Guo, Z.
Format: Article
Published: Elsevier Ltd 2022
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85126962611&doi=10.1016%2fj.dyepig.2022.110255&partnerID=40&md5=7c626310d21374e252da660000416eb2
http://eprints.utp.edu.my/33059/
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spelling my.utp.eprints.330592022-06-09T08:19:57Z Optimizing the photodynamic therapeutic effect of BODIPY-based photosensitizers against cancer and bacterial cells Masood, M.A. Wu, Y. Chen, Y. Yuan, H. Sher, N. Faiz, F. Yao, S. Qi, F. Khan, M.I. Ahmed, M. Mushtaq, N. He, W. Guo, Z. The initiation and propagation of cancer is closely associated with bacterial infection, which generally requires the simultaneous usage of anticancer drugs and antibiotics. However, the adverse effects have increased too much due to the multiple use of chemodrugs. To tackle this problem, a successful attempt has been made by developing two BODIPY-based cationic photosensitizers, 1BDPC-Py and 1BDPC-TPP, for treating both cancer and bacterial infection. Optimization of the basic design of these photosensitizers resulted in the red-light absorption, improved 1O2 generation yield, outstanding therapeutic effects and optical physical properties for excellent imaging. The decorated cationic groups grant some highly favorable features, such as a mediated hydrophilic-lipophilic balance for improving cell penetrability, specific mitochondrial anchoring for enhanced PDT and the increased attraction towards bacterial cells for efficient photoinactivation. As a result, these photosensitizers exhibited extremely high phototoxicity and phototoxic index (PI) against breast cancer cells along with promising photodynamic activity against two bacterial species and their corresponding antibiotic resistant strains. For example, 1BDPC-Py and 1BDPC-TPP have the values of 7.8 nM and 30 nM for IC50 along with 1539 and 720 for PI against the MCF-7 cells, respectively. Similarly, both 1BDPC-Py and 1BDPC-TPP decreased the viability of S. aureus and E. coli to almost 0 at 100 nM and 400 nM, respectively. Thus, to the best of our knowledge, both of these are the first excitable BODIPY-based photosensitizers in the therapeutic window for the precise treatment of both cancer and bacterial infection. © 2022 Elsevier Ltd 2022 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85126962611&doi=10.1016%2fj.dyepig.2022.110255&partnerID=40&md5=7c626310d21374e252da660000416eb2 Masood, M.A. and Wu, Y. and Chen, Y. and Yuan, H. and Sher, N. and Faiz, F. and Yao, S. and Qi, F. and Khan, M.I. and Ahmed, M. and Mushtaq, N. and He, W. and Guo, Z. (2022) Optimizing the photodynamic therapeutic effect of BODIPY-based photosensitizers against cancer and bacterial cells. Dyes and Pigments, 202 . http://eprints.utp.edu.my/33059/
institution Universiti Teknologi Petronas
building UTP Resource Centre
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Petronas
content_source UTP Institutional Repository
url_provider http://eprints.utp.edu.my/
description The initiation and propagation of cancer is closely associated with bacterial infection, which generally requires the simultaneous usage of anticancer drugs and antibiotics. However, the adverse effects have increased too much due to the multiple use of chemodrugs. To tackle this problem, a successful attempt has been made by developing two BODIPY-based cationic photosensitizers, 1BDPC-Py and 1BDPC-TPP, for treating both cancer and bacterial infection. Optimization of the basic design of these photosensitizers resulted in the red-light absorption, improved 1O2 generation yield, outstanding therapeutic effects and optical physical properties for excellent imaging. The decorated cationic groups grant some highly favorable features, such as a mediated hydrophilic-lipophilic balance for improving cell penetrability, specific mitochondrial anchoring for enhanced PDT and the increased attraction towards bacterial cells for efficient photoinactivation. As a result, these photosensitizers exhibited extremely high phototoxicity and phototoxic index (PI) against breast cancer cells along with promising photodynamic activity against two bacterial species and their corresponding antibiotic resistant strains. For example, 1BDPC-Py and 1BDPC-TPP have the values of 7.8 nM and 30 nM for IC50 along with 1539 and 720 for PI against the MCF-7 cells, respectively. Similarly, both 1BDPC-Py and 1BDPC-TPP decreased the viability of S. aureus and E. coli to almost 0 at 100 nM and 400 nM, respectively. Thus, to the best of our knowledge, both of these are the first excitable BODIPY-based photosensitizers in the therapeutic window for the precise treatment of both cancer and bacterial infection. © 2022
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author Masood, M.A.
Wu, Y.
Chen, Y.
Yuan, H.
Sher, N.
Faiz, F.
Yao, S.
Qi, F.
Khan, M.I.
Ahmed, M.
Mushtaq, N.
He, W.
Guo, Z.
spellingShingle Masood, M.A.
Wu, Y.
Chen, Y.
Yuan, H.
Sher, N.
Faiz, F.
Yao, S.
Qi, F.
Khan, M.I.
Ahmed, M.
Mushtaq, N.
He, W.
Guo, Z.
Optimizing the photodynamic therapeutic effect of BODIPY-based photosensitizers against cancer and bacterial cells
author_facet Masood, M.A.
Wu, Y.
Chen, Y.
Yuan, H.
Sher, N.
Faiz, F.
Yao, S.
Qi, F.
Khan, M.I.
Ahmed, M.
Mushtaq, N.
He, W.
Guo, Z.
author_sort Masood, M.A.
title Optimizing the photodynamic therapeutic effect of BODIPY-based photosensitizers against cancer and bacterial cells
title_short Optimizing the photodynamic therapeutic effect of BODIPY-based photosensitizers against cancer and bacterial cells
title_full Optimizing the photodynamic therapeutic effect of BODIPY-based photosensitizers against cancer and bacterial cells
title_fullStr Optimizing the photodynamic therapeutic effect of BODIPY-based photosensitizers against cancer and bacterial cells
title_full_unstemmed Optimizing the photodynamic therapeutic effect of BODIPY-based photosensitizers against cancer and bacterial cells
title_sort optimizing the photodynamic therapeutic effect of bodipy-based photosensitizers against cancer and bacterial cells
publisher Elsevier Ltd
publishDate 2022
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85126962611&doi=10.1016%2fj.dyepig.2022.110255&partnerID=40&md5=7c626310d21374e252da660000416eb2
http://eprints.utp.edu.my/33059/
_version_ 1738657449672441856
score 13.211869

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