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Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes

Five heteroleptic palladium(II) complexes of the general formula Pd(PR3)(tu)Cl2, where PR3 = triphenylphosphine (1), diphenyl-o-tolylphosphine (2), diphenyl-p-tolylphosphine (3), diphenyl-t-butylphosphine (4), and diphenyl-o-methoxyphenylphosphine (5), and tu = 1,3-bis(2-methoxyphenyl) thiourea. The...

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Main Authors: Khan, H., Daraz, N., Khan, M.N., Said, M., Akhtar, N., Badshah, A., Khan, A.S., Ali, M.
Format: Article
Published: Hindawi Publishing Corporation 2014
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-84935845137&doi=10.1155%2f2014%2f916361&partnerID=40&md5=bd37cf222286a396d630df430675f381
http://eprints.utp.edu.my/31749/
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spelling my.utp.eprints.317492022-03-29T03:36:33Z Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes Khan, H. Daraz, N. Khan, M.N. Said, M. Akhtar, N. Badshah, A. Khan, A.S. Ali, M. Five heteroleptic palladium(II) complexes of the general formula Pd(PR3)(tu)Cl2, where PR3 = triphenylphosphine (1), diphenyl-o-tolylphosphine (2), diphenyl-p-tolylphosphine (3), diphenyl-t-butylphosphine (4), and diphenyl-o-methoxyphenylphosphine (5), and tu = 1,3-bis(2-methoxyphenyl) thiourea. They all have been synthesized and characterized by various spectroscopic techniques (elemental analysis, FTIR, and 1H NMR and the ligand 1,3-bis(2-methoxyphenyl) thiourea was synthesized by single crystal X-ray diffraction technique). The synthesized compounds were screened for their antibacterial activity against four strains of bacteria (Escherichia coli, Shigella flexneri, Staphylococcus aureus, and Bacillus subtilis). The antitumor potential was evaluated in terms of activity against brine shrimp eggs and DNA interaction. The mixed ligand complexes have exhibited moderate antibacterial activity and promising antitumor potential. © 2014 Hizbullah Khan et al. Hindawi Publishing Corporation 2014 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-84935845137&doi=10.1155%2f2014%2f916361&partnerID=40&md5=bd37cf222286a396d630df430675f381 Khan, H. and Daraz, N. and Khan, M.N. and Said, M. and Akhtar, N. and Badshah, A. and Khan, A.S. and Ali, M. (2014) Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes. Bioinorganic Chemistry and Applications, 2014 . http://eprints.utp.edu.my/31749/
institution Universiti Teknologi Petronas
building UTP Resource Centre
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Petronas
content_source UTP Institutional Repository
url_provider http://eprints.utp.edu.my/
description Five heteroleptic palladium(II) complexes of the general formula Pd(PR3)(tu)Cl2, where PR3 = triphenylphosphine (1), diphenyl-o-tolylphosphine (2), diphenyl-p-tolylphosphine (3), diphenyl-t-butylphosphine (4), and diphenyl-o-methoxyphenylphosphine (5), and tu = 1,3-bis(2-methoxyphenyl) thiourea. They all have been synthesized and characterized by various spectroscopic techniques (elemental analysis, FTIR, and 1H NMR and the ligand 1,3-bis(2-methoxyphenyl) thiourea was synthesized by single crystal X-ray diffraction technique). The synthesized compounds were screened for their antibacterial activity against four strains of bacteria (Escherichia coli, Shigella flexneri, Staphylococcus aureus, and Bacillus subtilis). The antitumor potential was evaluated in terms of activity against brine shrimp eggs and DNA interaction. The mixed ligand complexes have exhibited moderate antibacterial activity and promising antitumor potential. © 2014 Hizbullah Khan et al.
format Article
author Khan, H.
Daraz, N.
Khan, M.N.
Said, M.
Akhtar, N.
Badshah, A.
Khan, A.S.
Ali, M.
spellingShingle Khan, H.
Daraz, N.
Khan, M.N.
Said, M.
Akhtar, N.
Badshah, A.
Khan, A.S.
Ali, M.
Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes
author_facet Khan, H.
Daraz, N.
Khan, M.N.
Said, M.
Akhtar, N.
Badshah, A.
Khan, A.S.
Ali, M.
author_sort Khan, H.
title Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes
title_short Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes
title_full Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes
title_fullStr Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes
title_full_unstemmed Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes
title_sort synthesis, structural characterization, and evaluation of the biological properties of heteroleptic palladium(ii) complexes
publisher Hindawi Publishing Corporation
publishDate 2014
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-84935845137&doi=10.1155%2f2014%2f916361&partnerID=40&md5=bd37cf222286a396d630df430675f381
http://eprints.utp.edu.my/31749/
_version_ 1738657291124604928
score 13.211869

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