Cover Image

Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model

Real-time impairment of ocular blood flow (OBF) under common carotid artery stenosis (CCAS) has not been ascertained. We aimed to longitudinally assess the impact of CCAS on OBF using a rabbit model. About 75 stenosis was created by tying the common carotid artery with a plastic mandrel using a nylo...

Full description

Saved in:
Bibliographic Details
Main Authors: Ismail, A., Chen, H.C., Faye, I., Tang, T.B.
Format: Article
Published: Nature Research 2020
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091643584&doi=10.1038%2fs41598-020-72556-9&partnerID=40&md5=67b8d8c6ca558b60dfbcda945f6995fa
http://eprints.utp.edu.my/29713/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.utp.eprints.29713
record_format eprints
spelling my.utp.eprints.297132022-03-25T02:45:24Z Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model Ismail, A. Chen, H.C. Faye, I. Tang, T.B. Real-time impairment of ocular blood flow (OBF) under common carotid artery stenosis (CCAS) has not been ascertained. We aimed to longitudinally assess the impact of CCAS on OBF using a rabbit model. About 75 stenosis was created by tying the common carotid artery with a plastic mandrel using a nylon suture. The plastic mandrel was gently removed, leaving a ligature. Neurological and behavioral assessments were recorded as the clinical indicator of stroke severity. With laser speckle flowgraphy, the pulse waveform parameters namely mean blur rate (MBR), blowout score (BOS), blowout time (BOT), rising rate, S1-area, falling rate (FR), S2-area, flow acceleration index (FAI), acceleration time index, resistive index (RI) and the difference between the maximum and minimum values of MBR (AC) were assessed in overall, vessel, and tissue regions of the optic nerve head (ONH). Longitudinally, BOS significantly increased until day 19 post-surgery, whereas FAI, RI, and AC significantly decreased. Beyond day 19, BOS, BOT, FR, FAI, RI, and AC significantly decreased. We defined two stages representing impaired vessel conditions, namely the vessel resistance phase, where BOS increases and FAI, RI, and AC decrease, and the vessel elasticity phase where BOS, BOT, FR, FAI, RI and AC decrease. These stages provide information about atherosclerosis, assessable non-invasively through the eye. © 2020, The Author(s). Nature Research 2020 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091643584&doi=10.1038%2fs41598-020-72556-9&partnerID=40&md5=67b8d8c6ca558b60dfbcda945f6995fa Ismail, A. and Chen, H.C. and Faye, I. and Tang, T.B. (2020) Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model. Scientific Reports, 10 (1). http://eprints.utp.edu.my/29713/
institution Universiti Teknologi Petronas
building UTP Resource Centre
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Petronas
content_source UTP Institutional Repository
url_provider http://eprints.utp.edu.my/
description Real-time impairment of ocular blood flow (OBF) under common carotid artery stenosis (CCAS) has not been ascertained. We aimed to longitudinally assess the impact of CCAS on OBF using a rabbit model. About 75 stenosis was created by tying the common carotid artery with a plastic mandrel using a nylon suture. The plastic mandrel was gently removed, leaving a ligature. Neurological and behavioral assessments were recorded as the clinical indicator of stroke severity. With laser speckle flowgraphy, the pulse waveform parameters namely mean blur rate (MBR), blowout score (BOS), blowout time (BOT), rising rate, S1-area, falling rate (FR), S2-area, flow acceleration index (FAI), acceleration time index, resistive index (RI) and the difference between the maximum and minimum values of MBR (AC) were assessed in overall, vessel, and tissue regions of the optic nerve head (ONH). Longitudinally, BOS significantly increased until day 19 post-surgery, whereas FAI, RI, and AC significantly decreased. Beyond day 19, BOS, BOT, FR, FAI, RI, and AC significantly decreased. We defined two stages representing impaired vessel conditions, namely the vessel resistance phase, where BOS increases and FAI, RI, and AC decrease, and the vessel elasticity phase where BOS, BOT, FR, FAI, RI and AC decrease. These stages provide information about atherosclerosis, assessable non-invasively through the eye. © 2020, The Author(s).
format Article
author Ismail, A.
Chen, H.C.
Faye, I.
Tang, T.B.
spellingShingle Ismail, A.
Chen, H.C.
Faye, I.
Tang, T.B.
Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model
author_facet Ismail, A.
Chen, H.C.
Faye, I.
Tang, T.B.
author_sort Ismail, A.
title Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model
title_short Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model
title_full Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model
title_fullStr Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model
title_full_unstemmed Longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model
title_sort longitudinal effects of common carotid artery stenosis on ocular hemodynamics assessed using laser speckle flowgraphy in a rabbit model
publisher Nature Research
publishDate 2020
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091643584&doi=10.1038%2fs41598-020-72556-9&partnerID=40&md5=67b8d8c6ca558b60dfbcda945f6995fa
http://eprints.utp.edu.my/29713/
_version_ 1738657005129695232
score 13.211869

Similar Items