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Preparation, characterization and stability evaluation of ionic liquid blended chitosan tripolyphosphate microparticles

Recently, drug delivery systems are facing several shortcomings which demand for the development of new formulations. A new drug�solvent systems may improve the characteristics and sustained release of drugs. Investigations in this domain revealed the significance of Ionic Liquids (ILs) as active...

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Main Authors: Safdar, R., Gnanasundaram, N., Iyyasami, R., Appusamy, A., Papadimitriou, S., Thanabalan, M.
Format: Article
Published: 2019
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060894616&doi=10.1016%2fj.jddst.2019.01.027&partnerID=40&md5=de5e8ed7a408b626f68e46d6de178de1
http://eprints.utp.edu.my/22108/
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spelling my.utp.eprints.221082019-02-28T08:00:16Z Preparation, characterization and stability evaluation of ionic liquid blended chitosan tripolyphosphate microparticles Safdar, R. Gnanasundaram, N. Iyyasami, R. Appusamy, A. Papadimitriou, S. Thanabalan, M. Recently, drug delivery systems are facing several shortcomings which demand for the development of new formulations. A new drug�solvent systems may improve the characteristics and sustained release of drugs. Investigations in this domain revealed the significance of Ionic Liquids (ILs) as active pharmaceutical ingredients for pharmaceutical applications. ILs�drug assisted carriers exhibit many unique and attractive properties which are lacking in their conventional counterparts. In this work, Chitosan (CS), a natural polymer was blended with an ammonium based IL, Tetramethylammonium hydroxide (TMAOH), and microparticles (MPs) of CS�TMAOH�TPP were synthesized by cross�linking with sodium tripolyphosphate (TPP) using ionic gelation method. The addition of TMAOH to CS enhanced the stability of MPs without affecting the particle size. FTIR analysis confirmed the structural changes whereas the FE-SEM analysis showed almost similar sizes of freeze�dried MPs as determined by Zetasizer. The morphology of the CS�TMAOH�TPP MPs was mostly similar to CS�TPP MPs. The Thermogravimetric analysis indicated that these MPs exhibit good thermal resistance. Moreover, the DSC and XRD analysis of the prepared MPs were conducted to analyze thermograms and crystallographic structure respectively. Overall, the present synthesized CS�TMAOH�TPP MPs are more stable than CS�TPP MPs, which will be useful for drug delivery applications. © 2019 2019 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060894616&doi=10.1016%2fj.jddst.2019.01.027&partnerID=40&md5=de5e8ed7a408b626f68e46d6de178de1 Safdar, R. and Gnanasundaram, N. and Iyyasami, R. and Appusamy, A. and Papadimitriou, S. and Thanabalan, M. (2019) Preparation, characterization and stability evaluation of ionic liquid blended chitosan tripolyphosphate microparticles. Journal of Drug Delivery Science and Technology, 50 . pp. 217-225. http://eprints.utp.edu.my/22108/
institution Universiti Teknologi Petronas
building UTP Resource Centre
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Petronas
content_source UTP Institutional Repository
url_provider http://eprints.utp.edu.my/
description Recently, drug delivery systems are facing several shortcomings which demand for the development of new formulations. A new drug�solvent systems may improve the characteristics and sustained release of drugs. Investigations in this domain revealed the significance of Ionic Liquids (ILs) as active pharmaceutical ingredients for pharmaceutical applications. ILs�drug assisted carriers exhibit many unique and attractive properties which are lacking in their conventional counterparts. In this work, Chitosan (CS), a natural polymer was blended with an ammonium based IL, Tetramethylammonium hydroxide (TMAOH), and microparticles (MPs) of CS�TMAOH�TPP were synthesized by cross�linking with sodium tripolyphosphate (TPP) using ionic gelation method. The addition of TMAOH to CS enhanced the stability of MPs without affecting the particle size. FTIR analysis confirmed the structural changes whereas the FE-SEM analysis showed almost similar sizes of freeze�dried MPs as determined by Zetasizer. The morphology of the CS�TMAOH�TPP MPs was mostly similar to CS�TPP MPs. The Thermogravimetric analysis indicated that these MPs exhibit good thermal resistance. Moreover, the DSC and XRD analysis of the prepared MPs were conducted to analyze thermograms and crystallographic structure respectively. Overall, the present synthesized CS�TMAOH�TPP MPs are more stable than CS�TPP MPs, which will be useful for drug delivery applications. © 2019
format Article
author Safdar, R.
Gnanasundaram, N.
Iyyasami, R.
Appusamy, A.
Papadimitriou, S.
Thanabalan, M.
spellingShingle Safdar, R.
Gnanasundaram, N.
Iyyasami, R.
Appusamy, A.
Papadimitriou, S.
Thanabalan, M.
Preparation, characterization and stability evaluation of ionic liquid blended chitosan tripolyphosphate microparticles
author_facet Safdar, R.
Gnanasundaram, N.
Iyyasami, R.
Appusamy, A.
Papadimitriou, S.
Thanabalan, M.
author_sort Safdar, R.
title Preparation, characterization and stability evaluation of ionic liquid blended chitosan tripolyphosphate microparticles
title_short Preparation, characterization and stability evaluation of ionic liquid blended chitosan tripolyphosphate microparticles
title_full Preparation, characterization and stability evaluation of ionic liquid blended chitosan tripolyphosphate microparticles
title_fullStr Preparation, characterization and stability evaluation of ionic liquid blended chitosan tripolyphosphate microparticles
title_full_unstemmed Preparation, characterization and stability evaluation of ionic liquid blended chitosan tripolyphosphate microparticles
title_sort preparation, characterization and stability evaluation of ionic liquid blended chitosan tripolyphosphate microparticles
publishDate 2019
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060894616&doi=10.1016%2fj.jddst.2019.01.027&partnerID=40&md5=de5e8ed7a408b626f68e46d6de178de1
http://eprints.utp.edu.my/22108/
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score 13.211869

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