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Formulation and characterization of acetate based ionic liquid in oil microemulsion as a carrier for acyclovir and methotrexate

Ionic Liquid (ILs) in oil microemulsions (IL/O MEs) have emerged as a potential carrier for transdermal drug delivery, particularly for sparingly soluble drug molecules, such as acyclovir and methotrexate. However, less attention was paid in the selection of non-toxic and biodegradable ILs. In this...

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Main Authors:	Kandasamy, S., Moniruzzaman, M., Sivapragasam, M., Shamsuddin, M.R., Mutalib, M.I.A.
Format:	Article
Published:	Elsevier B.V. 2018
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028302500&doi=10.1016%2fj.seppur.2017.08.044&partnerID=40&md5=2a8a7d0627e5e9fbf4794a9036b0a71d http://eprints.utp.edu.my/20924/
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spelling	my.utp.eprints.209242019-02-26T02:44:28Z Formulation and characterization of acetate based ionic liquid in oil microemulsion as a carrier for acyclovir and methotrexate Kandasamy, S. Moniruzzaman, M. Sivapragasam, M. Shamsuddin, M.R. Mutalib, M.I.A. Ionic Liquid (ILs) in oil microemulsions (IL/O MEs) have emerged as a potential carrier for transdermal drug delivery, particularly for sparingly soluble drug molecules, such as acyclovir and methotrexate. However, less attention was paid in the selection of non-toxic and biodegradable ILs. In this paper, we report new IL/O MEs with ammonium acetate ILs, which can dissolve acyclovir and methotrexate significantly. Microemulsions were composed of a mixture of nonionic surfactants, polyoxyethylene sorbitan monooleate (Tween-80), and sorbitan laurate (Span-20)/ILs/oil isopropyl myristate (IPM). Three ILs called 1-ethyl-3-methylimidazolium acetate (EMIMOAc), triethylammonium acetate (TEAOAc) and diethylammonium acetate (DEAOAc) were selected due to their non-toxic property. Based on the pseudo-ternary diagrams constructed, it was evident that Span-20 played the key role as a surfactant while Tween-80 acted as the co-surfactant, showing optimal dissolution of the ILs into the system prepared with a ratio of 1:3 (Tween 80:Span20). This binary mixture also depicted the lowest viscosity, which is favorable as a carrier agent in drug delivery. The incorporation of various ILs into microemulsions resulted in a particle size ranging from 11 to 39.7 nm at diverse drug loading capacity. The formulation with IL TEAOAc and IL DEAOAc displayed substantial drug carrying capacity and stability compared to the commercially available IL EMIMOAc loaded system. Â© 2017 Elsevier B.V. Elsevier B.V. 2018 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028302500&doi=10.1016%2fj.seppur.2017.08.044&partnerID=40&md5=2a8a7d0627e5e9fbf4794a9036b0a71d Kandasamy, S. and Moniruzzaman, M. and Sivapragasam, M. and Shamsuddin, M.R. and Mutalib, M.I.A. (2018) Formulation and characterization of acetate based ionic liquid in oil microemulsion as a carrier for acyclovir and methotrexate. Separation and Purification Technology, 196 . pp. 149-156. http://eprints.utp.edu.my/20924/
institution	Universiti Teknologi Petronas
building	UTP Resource Centre
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Petronas
content_source	UTP Institutional Repository
url_provider	http://eprints.utp.edu.my/
description	Ionic Liquid (ILs) in oil microemulsions (IL/O MEs) have emerged as a potential carrier for transdermal drug delivery, particularly for sparingly soluble drug molecules, such as acyclovir and methotrexate. However, less attention was paid in the selection of non-toxic and biodegradable ILs. In this paper, we report new IL/O MEs with ammonium acetate ILs, which can dissolve acyclovir and methotrexate significantly. Microemulsions were composed of a mixture of nonionic surfactants, polyoxyethylene sorbitan monooleate (Tween-80), and sorbitan laurate (Span-20)/ILs/oil isopropyl myristate (IPM). Three ILs called 1-ethyl-3-methylimidazolium acetate (EMIMOAc), triethylammonium acetate (TEAOAc) and diethylammonium acetate (DEAOAc) were selected due to their non-toxic property. Based on the pseudo-ternary diagrams constructed, it was evident that Span-20 played the key role as a surfactant while Tween-80 acted as the co-surfactant, showing optimal dissolution of the ILs into the system prepared with a ratio of 1:3 (Tween 80:Span20). This binary mixture also depicted the lowest viscosity, which is favorable as a carrier agent in drug delivery. The incorporation of various ILs into microemulsions resulted in a particle size ranging from 11 to 39.7 nm at diverse drug loading capacity. The formulation with IL TEAOAc and IL DEAOAc displayed substantial drug carrying capacity and stability compared to the commercially available IL EMIMOAc loaded system. Â© 2017 Elsevier B.V.
format	Article
author	Kandasamy, S. Moniruzzaman, M. Sivapragasam, M. Shamsuddin, M.R. Mutalib, M.I.A.
spellingShingle	Kandasamy, S. Moniruzzaman, M. Sivapragasam, M. Shamsuddin, M.R. Mutalib, M.I.A. Formulation and characterization of acetate based ionic liquid in oil microemulsion as a carrier for acyclovir and methotrexate
author_facet	Kandasamy, S. Moniruzzaman, M. Sivapragasam, M. Shamsuddin, M.R. Mutalib, M.I.A.
author_sort	Kandasamy, S.
title	Formulation and characterization of acetate based ionic liquid in oil microemulsion as a carrier for acyclovir and methotrexate
title_short	Formulation and characterization of acetate based ionic liquid in oil microemulsion as a carrier for acyclovir and methotrexate
title_full	Formulation and characterization of acetate based ionic liquid in oil microemulsion as a carrier for acyclovir and methotrexate
title_fullStr	Formulation and characterization of acetate based ionic liquid in oil microemulsion as a carrier for acyclovir and methotrexate
title_full_unstemmed	Formulation and characterization of acetate based ionic liquid in oil microemulsion as a carrier for acyclovir and methotrexate
title_sort	formulation and characterization of acetate based ionic liquid in oil microemulsion as a carrier for acyclovir and methotrexate
publisher	Elsevier B.V.
publishDate	2018
url	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028302500&doi=10.1016%2fj.seppur.2017.08.044&partnerID=40&md5=2a8a7d0627e5e9fbf4794a9036b0a71d http://eprints.utp.edu.my/20924/
_version_	1738656251249688576
score	13.211869

Formulation and characterization of acetate based ionic liquid in oil microemulsion as a carrier for acyclovir and methotrexate

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