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Ionic liquid as a potential solvent for preparation of collagen-alginate-hydroxyapatite beads as bone filler

In this study, collagen/alginate/hydroxyapatite beads having different proportions were prepared as bone fillers for the restoration of osteological defects. Ionic liquid was used to dissolve the collagen and subsequently the solution was mixed with sodium alginate solution. Hydroxyapatite was added...

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Main Authors: Iqbal, B., Sarfaraz, Z., Muhammad, N., Ahmad, P., Iqbal, J., Khan, Z.U.H., Gonfa, G., Iqbal, F., Jamal, A., Rahim, A.
Format: Article
Published: Taylor and Francis Inc. 2018
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042919247&doi=10.1080%2f09205063.2018.1443604&partnerID=40&md5=57958c5d6aed7f848a5ea9a33b48001d
http://eprints.utp.edu.my/20809/
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spelling my.utp.eprints.208092019-02-26T02:25:25Z Ionic liquid as a potential solvent for preparation of collagen-alginate-hydroxyapatite beads as bone filler Iqbal, B. Sarfaraz, Z. Muhammad, N. Ahmad, P. Iqbal, J. Khan, Z.U.H. Gonfa, G. Iqbal, F. Jamal, A. Rahim, A. In this study, collagen/alginate/hydroxyapatite beads having different proportions were prepared as bone fillers for the restoration of osteological defects. Ionic liquid was used to dissolve the collagen and subsequently the solution was mixed with sodium alginate solution. Hydroxyapatite was added in different proportions, with the rationale to enhance mechanical as well as biological properties. The prepared solutions were given characteristic bead shapes by dropwise addition into calcium chloride solution. The prepared beads were characterized using FTIR, XRD, TGA and SEM analysis. Microhardness testing was used to evaluate the mechanical properties. The prepared beads were investigated for water adsorption behavior to ascertain its ability for body fluid uptake and adjusted accordingly to the bone cavity. Drug loading and subsequently the antibacterial activity was investigated for the prepared beads. The biocompatibility was assessed using the hemolysis testing and cell proliferation assay. The prepared collagen-alginate-HA beads, having biocompatibility and good mechanical properties, have showed an option of promising biologically active bone fillers for bone regeneration. © 2018 Informa UK Limited, trading as Taylor & Francis Group. Taylor and Francis Inc. 2018 Article NonPeerReviewed https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042919247&doi=10.1080%2f09205063.2018.1443604&partnerID=40&md5=57958c5d6aed7f848a5ea9a33b48001d Iqbal, B. and Sarfaraz, Z. and Muhammad, N. and Ahmad, P. and Iqbal, J. and Khan, Z.U.H. and Gonfa, G. and Iqbal, F. and Jamal, A. and Rahim, A. (2018) Ionic liquid as a potential solvent for preparation of collagen-alginate-hydroxyapatite beads as bone filler. Journal of Biomaterials Science, Polymer Edition, 29 (10). pp. 1168-1184. http://eprints.utp.edu.my/20809/
institution Universiti Teknologi Petronas
building UTP Resource Centre
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Petronas
content_source UTP Institutional Repository
url_provider http://eprints.utp.edu.my/
description In this study, collagen/alginate/hydroxyapatite beads having different proportions were prepared as bone fillers for the restoration of osteological defects. Ionic liquid was used to dissolve the collagen and subsequently the solution was mixed with sodium alginate solution. Hydroxyapatite was added in different proportions, with the rationale to enhance mechanical as well as biological properties. The prepared solutions were given characteristic bead shapes by dropwise addition into calcium chloride solution. The prepared beads were characterized using FTIR, XRD, TGA and SEM analysis. Microhardness testing was used to evaluate the mechanical properties. The prepared beads were investigated for water adsorption behavior to ascertain its ability for body fluid uptake and adjusted accordingly to the bone cavity. Drug loading and subsequently the antibacterial activity was investigated for the prepared beads. The biocompatibility was assessed using the hemolysis testing and cell proliferation assay. The prepared collagen-alginate-HA beads, having biocompatibility and good mechanical properties, have showed an option of promising biologically active bone fillers for bone regeneration. © 2018 Informa UK Limited, trading as Taylor & Francis Group.
format Article
author Iqbal, B.
Sarfaraz, Z.
Muhammad, N.
Ahmad, P.
Iqbal, J.
Khan, Z.U.H.
Gonfa, G.
Iqbal, F.
Jamal, A.
Rahim, A.
spellingShingle Iqbal, B.
Sarfaraz, Z.
Muhammad, N.
Ahmad, P.
Iqbal, J.
Khan, Z.U.H.
Gonfa, G.
Iqbal, F.
Jamal, A.
Rahim, A.
Ionic liquid as a potential solvent for preparation of collagen-alginate-hydroxyapatite beads as bone filler
author_facet Iqbal, B.
Sarfaraz, Z.
Muhammad, N.
Ahmad, P.
Iqbal, J.
Khan, Z.U.H.
Gonfa, G.
Iqbal, F.
Jamal, A.
Rahim, A.
author_sort Iqbal, B.
title Ionic liquid as a potential solvent for preparation of collagen-alginate-hydroxyapatite beads as bone filler
title_short Ionic liquid as a potential solvent for preparation of collagen-alginate-hydroxyapatite beads as bone filler
title_full Ionic liquid as a potential solvent for preparation of collagen-alginate-hydroxyapatite beads as bone filler
title_fullStr Ionic liquid as a potential solvent for preparation of collagen-alginate-hydroxyapatite beads as bone filler
title_full_unstemmed Ionic liquid as a potential solvent for preparation of collagen-alginate-hydroxyapatite beads as bone filler
title_sort ionic liquid as a potential solvent for preparation of collagen-alginate-hydroxyapatite beads as bone filler
publisher Taylor and Francis Inc.
publishDate 2018
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042919247&doi=10.1080%2f09205063.2018.1443604&partnerID=40&md5=57958c5d6aed7f848a5ea9a33b48001d
http://eprints.utp.edu.my/20809/
_version_ 1738656235935236096
score 13.211869

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