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In-vivo blood glucose control by phenolic compound from Vernonia amygdalina, Andrographis paniculata, and Pithecellobium jiringa in Streptozotoxin-induced diabetic rats

Phenolic compound from three plant species, Vernonia amygdalina, Andrographis paniculata, and Pithecellobium jiringa were extracted with 40, 50 and 60% ethanol in steam water bath shaker. The Gallic acid as phenolic compound representative was determined by HPLC. Among the three selected plants, Pit...

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Main Authors: Mohd Zain, Asna, Abu, Amirul
Format: Citation Index Journal
Published: 2014
Subjects:
R Medicine (General)
RM Therapeutics. Pharmacology
Online Access:http://eprints.utp.edu.my/11360/1/AEB8%2814%29131-134.pdf
http://eprints.utp.edu.my/11360/
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spelling my.utp.eprints.113602015-04-28T02:54:06Z In-vivo blood glucose control by phenolic compound from Vernonia amygdalina, Andrographis paniculata, and Pithecellobium jiringa in Streptozotoxin-induced diabetic rats Mohd Zain, Asna Abu, Amirul R Medicine (General) RM Therapeutics. Pharmacology Phenolic compound from three plant species, Vernonia amygdalina, Andrographis paniculata, and Pithecellobium jiringa were extracted with 40, 50 and 60% ethanol in steam water bath shaker. The Gallic acid as phenolic compound representative was determined by HPLC. Among the three selected plants, Pithecellobium jiringa contains the highest amount of Gallic acid. The plant extracts were orally dosed to Streptozotoxin-induced diabetic rats. The rat’s blood glucose was monitored for dose response toward Gallic acid. Significant amount of blood glucose reduction was found after 15 days of treatment of the plant extracts solution containing Gallic acid with the maximum of 31 % reduction shown by 25 mg/mL of Pithecellobium jiringa dosed. Plant phenolic compound from Pithecellobium jiringa shows good potential for the treatment of diabetic Type 2. 2014-09 Citation Index Journal PeerReviewed application/pdf http://eprints.utp.edu.my/11360/1/AEB8%2814%29131-134.pdf Mohd Zain, Asna and Abu, Amirul (2014) In-vivo blood glucose control by phenolic compound from Vernonia amygdalina, Andrographis paniculata, and Pithecellobium jiringa in Streptozotoxin-induced diabetic rats. [Citation Index Journal] http://eprints.utp.edu.my/11360/
institution Universiti Teknologi Petronas
building UTP Resource Centre
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Petronas
content_source UTP Institutional Repository
url_provider http://eprints.utp.edu.my/
topic R Medicine (General)
RM Therapeutics. Pharmacology
spellingShingle R Medicine (General)
RM Therapeutics. Pharmacology
Mohd Zain, Asna
Abu, Amirul
In-vivo blood glucose control by phenolic compound from Vernonia amygdalina, Andrographis paniculata, and Pithecellobium jiringa in Streptozotoxin-induced diabetic rats
description Phenolic compound from three plant species, Vernonia amygdalina, Andrographis paniculata, and Pithecellobium jiringa were extracted with 40, 50 and 60% ethanol in steam water bath shaker. The Gallic acid as phenolic compound representative was determined by HPLC. Among the three selected plants, Pithecellobium jiringa contains the highest amount of Gallic acid. The plant extracts were orally dosed to Streptozotoxin-induced diabetic rats. The rat’s blood glucose was monitored for dose response toward Gallic acid. Significant amount of blood glucose reduction was found after 15 days of treatment of the plant extracts solution containing Gallic acid with the maximum of 31 % reduction shown by 25 mg/mL of Pithecellobium jiringa dosed. Plant phenolic compound from Pithecellobium jiringa shows good potential for the treatment of diabetic Type 2.
format Citation Index Journal
author Mohd Zain, Asna
Abu, Amirul
author_facet Mohd Zain, Asna
Abu, Amirul
author_sort Mohd Zain, Asna
title In-vivo blood glucose control by phenolic compound from Vernonia amygdalina, Andrographis paniculata, and Pithecellobium jiringa in Streptozotoxin-induced diabetic rats
title_short In-vivo blood glucose control by phenolic compound from Vernonia amygdalina, Andrographis paniculata, and Pithecellobium jiringa in Streptozotoxin-induced diabetic rats
title_full In-vivo blood glucose control by phenolic compound from Vernonia amygdalina, Andrographis paniculata, and Pithecellobium jiringa in Streptozotoxin-induced diabetic rats
title_fullStr In-vivo blood glucose control by phenolic compound from Vernonia amygdalina, Andrographis paniculata, and Pithecellobium jiringa in Streptozotoxin-induced diabetic rats
title_full_unstemmed In-vivo blood glucose control by phenolic compound from Vernonia amygdalina, Andrographis paniculata, and Pithecellobium jiringa in Streptozotoxin-induced diabetic rats
title_sort in-vivo blood glucose control by phenolic compound from vernonia amygdalina, andrographis paniculata, and pithecellobium jiringa in streptozotoxin-induced diabetic rats
publishDate 2014
url http://eprints.utp.edu.my/11360/1/AEB8%2814%29131-134.pdf
http://eprints.utp.edu.my/11360/
_version_ 1738655945537355776
score 13.211869

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