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tailoring the everolimus immobilisation time on poly (l-lactic acid/poly (d-lactic acid) scaffold for biodegradable stent coating development

Biodegradable stents (BDS) are projected to be degraded while supporting the blood vessel lumen. Equipping BDS with coated drugs will enhance its biological properties. In this study, everolimus drug was coated on poly (L-lactic acid) (PLLA)/poly (D-lactic acid) (PDLA) scaffolds by utilising polydop...

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Main Authors: Pupathi, Jeysheni Shree, Jumat, Mohamad Amin, Muhamad Zain, Norhidayu, Saidin, Syafiqah
Format: Conference or Workshop Item
Published: 2022
Subjects:
Q Science (General)
Online Access:http://eprints.utm.my/id/eprint/98840/
http://dx.doi.org/10.4028/p-u3b7dr
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spelling my.utm.988402023-02-02T09:35:19Z http://eprints.utm.my/id/eprint/98840/ tailoring the everolimus immobilisation time on poly (l-lactic acid/poly (d-lactic acid) scaffold for biodegradable stent coating development Pupathi, Jeysheni Shree Jumat, Mohamad Amin Muhamad Zain, Norhidayu Saidin, Syafiqah Q Science (General) Biodegradable stents (BDS) are projected to be degraded while supporting the blood vessel lumen. Equipping BDS with coated drugs will enhance its biological properties. In this study, everolimus drug was coated on poly (L-lactic acid) (PLLA)/poly (D-lactic acid) (PDLA) scaffolds by utilising polydopamine (PDA) as an intermediate layer. The immobilisation time for the coating process was tailored at 12 and 24 hours. The effects of different immobilisation time of everolimus (12 and 24 hours) were characterised through an ATR-FTIR, SEM and water contact angle analyses to investigate the chemical functionalities, surface morphology and hydrophilicity properties, respectively. The ATR-FTIR results indicated the presence of chemical functionalities of the coating and the scaffolds. The scaffold surfaces were having a transition from smooth to irregular surfaces after the PDA grafting and the coating of everolimus. More homogeneous surface formation was observed and greater hydrophilicity was recorded on the PLLA/PDLA scaffolds coated with everolimus at 24 hours immobilisation compared to the 12 hours immobilisation. These findings are beneficial for the fabrication of BDS with the implementation of everolimus and PDA as coating materials. 2022 Conference or Workshop Item PeerReviewed Pupathi, Jeysheni Shree and Jumat, Mohamad Amin and Muhamad Zain, Norhidayu and Saidin, Syafiqah (2022) tailoring the everolimus immobilisation time on poly (l-lactic acid/poly (d-lactic acid) scaffold for biodegradable stent coating development. In: 6th International Conference on Materials Technology and Applications (ICMTA 2021), 30 October 2021 - 2 November 2021, Fukuoka, Japan. http://dx.doi.org/10.4028/p-u3b7dr
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic Q Science (General)
spellingShingle Q Science (General)
Pupathi, Jeysheni Shree
Jumat, Mohamad Amin
Muhamad Zain, Norhidayu
Saidin, Syafiqah
tailoring the everolimus immobilisation time on poly (l-lactic acid/poly (d-lactic acid) scaffold for biodegradable stent coating development
description Biodegradable stents (BDS) are projected to be degraded while supporting the blood vessel lumen. Equipping BDS with coated drugs will enhance its biological properties. In this study, everolimus drug was coated on poly (L-lactic acid) (PLLA)/poly (D-lactic acid) (PDLA) scaffolds by utilising polydopamine (PDA) as an intermediate layer. The immobilisation time for the coating process was tailored at 12 and 24 hours. The effects of different immobilisation time of everolimus (12 and 24 hours) were characterised through an ATR-FTIR, SEM and water contact angle analyses to investigate the chemical functionalities, surface morphology and hydrophilicity properties, respectively. The ATR-FTIR results indicated the presence of chemical functionalities of the coating and the scaffolds. The scaffold surfaces were having a transition from smooth to irregular surfaces after the PDA grafting and the coating of everolimus. More homogeneous surface formation was observed and greater hydrophilicity was recorded on the PLLA/PDLA scaffolds coated with everolimus at 24 hours immobilisation compared to the 12 hours immobilisation. These findings are beneficial for the fabrication of BDS with the implementation of everolimus and PDA as coating materials.
format Conference or Workshop Item
author Pupathi, Jeysheni Shree
Jumat, Mohamad Amin
Muhamad Zain, Norhidayu
Saidin, Syafiqah
author_facet Pupathi, Jeysheni Shree
Jumat, Mohamad Amin
Muhamad Zain, Norhidayu
Saidin, Syafiqah
author_sort Pupathi, Jeysheni Shree
title tailoring the everolimus immobilisation time on poly (l-lactic acid/poly (d-lactic acid) scaffold for biodegradable stent coating development
title_short tailoring the everolimus immobilisation time on poly (l-lactic acid/poly (d-lactic acid) scaffold for biodegradable stent coating development
title_full tailoring the everolimus immobilisation time on poly (l-lactic acid/poly (d-lactic acid) scaffold for biodegradable stent coating development
title_fullStr tailoring the everolimus immobilisation time on poly (l-lactic acid/poly (d-lactic acid) scaffold for biodegradable stent coating development
title_full_unstemmed tailoring the everolimus immobilisation time on poly (l-lactic acid/poly (d-lactic acid) scaffold for biodegradable stent coating development
title_sort tailoring the everolimus immobilisation time on poly (l-lactic acid/poly (d-lactic acid) scaffold for biodegradable stent coating development
publishDate 2022
url http://eprints.utm.my/id/eprint/98840/
http://dx.doi.org/10.4028/p-u3b7dr
_version_ 1758578026735468544
score 13.211869

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