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Synthesis, molecular docking and biochemical analysis of aminoalkylated naphthalene-based chalcones as acetylcholinesterase inhibitors

Twelve novel chalcones were synthesized using 2-alkyloxy-naphthaldehydes and Mannich bases of 4-hydroxyacetophenone. The chalcones were characterized using FTIR, 1D and 2D NMR and HRMS spectroscopy. Comparative docking analysis was carried out to screen their affinity towards the AChE enzyme (PDB 1E...

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Bibliographic Details
Main Authors: Aljohani, Ghadah, Al-Sheikh Ali, Adeeb, Alraqa, Shaya Y., Amran, Syazwani Itri, Basar, Norazah
Format: Article
Language:English
Published: Informa UK Limited 2021
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/id/eprint/97601/1/NorazahBasar2021_SynthesisMolecularDockingAndBiochemicalAnalysis.pdf
http://eprints.utm.my/id/eprint/97601/
http://dx.doi.org/10.1080/16583655.2021.2005921
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Internet

http://eprints.utm.my/id/eprint/97601/1/NorazahBasar2021_SynthesisMolecularDockingAndBiochemicalAnalysis.pdf
http://eprints.utm.my/id/eprint/97601/
http://dx.doi.org/10.1080/16583655.2021.2005921

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