Cover Image

Role of FOXP3 gene polymorphisms (SNPs rs3761547, rs3761549, and rs2232365) in the development of Type 2 diabetes mellitus

Type 2 diabetes mellitus (T2DM) is a multifactorial disease induced by an intricated interaction of several genetic variants and multiples environmental factors. A total of 281 patients diagnosed with T2DM and 281 non-diabetic control were enrolled in this study. Three SNPs (rs3761547, rs3761549, an...

Full description

Saved in:
Bibliographic Details
Main Authors: Chua, Lee Suan, Dawood, Dawood Ali Salim, Tan, Tian Swee, Ahmed Fadhil, Alshemary
Format: Article
Published: Elsevier Inc. 2021
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/97383/
http://dx.doi.org/10.1016/j.genrep.2021.101253
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.utm.97383
record_format eprints
spelling my.utm.973832022-10-10T04:24:10Z http://eprints.utm.my/id/eprint/97383/ Role of FOXP3 gene polymorphisms (SNPs rs3761547, rs3761549, and rs2232365) in the development of Type 2 diabetes mellitus Chua, Lee Suan Dawood, Dawood Ali Salim Tan, Tian Swee Ahmed Fadhil, Alshemary TP Chemical technology Type 2 diabetes mellitus (T2DM) is a multifactorial disease induced by an intricated interaction of several genetic variants and multiples environmental factors. A total of 281 patients diagnosed with T2DM and 281 non-diabetic control were enrolled in this study. Three SNPs (rs3761547, rs3761549, and rs2232365) in the FOXP3 gene were selected to study their role in the development of T2DM and T2DM-associated hypertension in an Iraqi population. The DNA extraction and genotyping were performed using allele-specific PCR. Our results showed that 212 patients were positive for a family history of T2DM, and 69 patients were negative (P < 0.001). The distribution of the rs3761547 genotypes among the diabetic patients with a positive family history was statistically significant (P < 0.001). Moreover, 205 patients were positive for hypertension, and 76 patients were negative (P < 0.001). The distribution of the rs3761547 genotypes among the diabetic patients with hypertension was statistically significant (P < 0.001). Furthermore, there was a statistical association for the rs3761549 genotype distribution among the diabetic patients without hypertension (P = 0.038). The correlation of the rs3761547 genotypes between the patients and controls was strongly significant for AA, GG, and AG (P < 0.001, P < 0.001, and P < 0.001, respectively). In contrast, there was no statistical significance for the rs3761549 genotypes (CC, TT, and CT; P = 0.362, P = 0.584, and P = 0.140, respectively). The rs2232365 (GG) genotype revealed a significant relationship (P < 0.001), while no statistical significance was displayed for the AA genotype (P = 0.130) and the AG genotype (P = 0.081). We concluded the FOXP3 gene polymorphisms rs3761547 and rs2232365 are linked with T2DM, while rs3761549 is not. Elsevier Inc. 2021 Article PeerReviewed Chua, Lee Suan and Dawood, Dawood Ali Salim and Tan, Tian Swee and Ahmed Fadhil, Alshemary (2021) Role of FOXP3 gene polymorphisms (SNPs rs3761547, rs3761549, and rs2232365) in the development of Type 2 diabetes mellitus. Gene Reports, 24 (NA). pp. 1-5. ISSN 2452-0144 http://dx.doi.org/10.1016/j.genrep.2021.101253 DOI : 10.1016/j.genrep.2021.101253
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Chua, Lee Suan
Dawood, Dawood Ali Salim
Tan, Tian Swee
Ahmed Fadhil, Alshemary
Role of FOXP3 gene polymorphisms (SNPs rs3761547, rs3761549, and rs2232365) in the development of Type 2 diabetes mellitus
description Type 2 diabetes mellitus (T2DM) is a multifactorial disease induced by an intricated interaction of several genetic variants and multiples environmental factors. A total of 281 patients diagnosed with T2DM and 281 non-diabetic control were enrolled in this study. Three SNPs (rs3761547, rs3761549, and rs2232365) in the FOXP3 gene were selected to study their role in the development of T2DM and T2DM-associated hypertension in an Iraqi population. The DNA extraction and genotyping were performed using allele-specific PCR. Our results showed that 212 patients were positive for a family history of T2DM, and 69 patients were negative (P < 0.001). The distribution of the rs3761547 genotypes among the diabetic patients with a positive family history was statistically significant (P < 0.001). Moreover, 205 patients were positive for hypertension, and 76 patients were negative (P < 0.001). The distribution of the rs3761547 genotypes among the diabetic patients with hypertension was statistically significant (P < 0.001). Furthermore, there was a statistical association for the rs3761549 genotype distribution among the diabetic patients without hypertension (P = 0.038). The correlation of the rs3761547 genotypes between the patients and controls was strongly significant for AA, GG, and AG (P < 0.001, P < 0.001, and P < 0.001, respectively). In contrast, there was no statistical significance for the rs3761549 genotypes (CC, TT, and CT; P = 0.362, P = 0.584, and P = 0.140, respectively). The rs2232365 (GG) genotype revealed a significant relationship (P < 0.001), while no statistical significance was displayed for the AA genotype (P = 0.130) and the AG genotype (P = 0.081). We concluded the FOXP3 gene polymorphisms rs3761547 and rs2232365 are linked with T2DM, while rs3761549 is not.
format Article
author Chua, Lee Suan
Dawood, Dawood Ali Salim
Tan, Tian Swee
Ahmed Fadhil, Alshemary
author_facet Chua, Lee Suan
Dawood, Dawood Ali Salim
Tan, Tian Swee
Ahmed Fadhil, Alshemary
author_sort Chua, Lee Suan
title Role of FOXP3 gene polymorphisms (SNPs rs3761547, rs3761549, and rs2232365) in the development of Type 2 diabetes mellitus
title_short Role of FOXP3 gene polymorphisms (SNPs rs3761547, rs3761549, and rs2232365) in the development of Type 2 diabetes mellitus
title_full Role of FOXP3 gene polymorphisms (SNPs rs3761547, rs3761549, and rs2232365) in the development of Type 2 diabetes mellitus
title_fullStr Role of FOXP3 gene polymorphisms (SNPs rs3761547, rs3761549, and rs2232365) in the development of Type 2 diabetes mellitus
title_full_unstemmed Role of FOXP3 gene polymorphisms (SNPs rs3761547, rs3761549, and rs2232365) in the development of Type 2 diabetes mellitus
title_sort role of foxp3 gene polymorphisms (snps rs3761547, rs3761549, and rs2232365) in the development of type 2 diabetes mellitus
publisher Elsevier Inc.
publishDate 2021
url http://eprints.utm.my/id/eprint/97383/
http://dx.doi.org/10.1016/j.genrep.2021.101253
_version_ 1748180451796713472
score 13.211869

Similar Items