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Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture

Ginger has been proven to possess various therapeutic effects, including antibacterial, anticancer, anti-inflammatory, and antioxidant effects. However, data on the comparison of ginger antioxidant activity with that of other natural products are still lacking. This study aimed to analyse and compar...

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Main Authors: Mohd. Sahardi, Nur Fatin Nabilah, Jaafar, Faizul, Zakaria, Siti Nor Asyikin, Tan, Jen Kit, Mad Nordin, Mariam Firdhaus, Makpol, Suzana
Format: Article
Language:English
Published: Penerbit Universiti Kebangsaan Malaysia 2021
Subjects:
T Technology (General)
Online Access:http://eprints.utm.my/id/eprint/97276/1/MariamFirdhaus2021_ComparisonoftheAntioxidantActivityofMalaysianGinger.pdf
http://eprints.utm.my/id/eprint/97276/
http://dx.doi.org/10.17576/jsm-2021-5005-23
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spelling my.utm.972762022-09-28T07:46:47Z http://eprints.utm.my/id/eprint/97276/ Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture Mohd. Sahardi, Nur Fatin Nabilah Jaafar, Faizul Zakaria, Siti Nor Asyikin Tan, Jen Kit Mad Nordin, Mariam Firdhaus Makpol, Suzana T Technology (General) Ginger has been proven to possess various therapeutic effects, including antibacterial, anticancer, anti-inflammatory, and antioxidant effects. However, data on the comparison of ginger antioxidant activity with that of other natural products are still lacking. This study aimed to analyse and compare the antioxidant properties of two types of Malaysian ginger extracts (GE1 and GE2) with that of selected natural products. The antioxidant activities were measured by 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and ferric reducing antioxidant power (FRAP) assays, while cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfonyl)-2H-tetrazolium (MTS) assay. The order of the DPPH scavenging activities was as follows: vitamin C > palm tocotrienol-rich fraction (TRF) > a-tocopherol > N-acetylcysteine (NAC) > Ficus deltoidea > butylated hydroxytoluene (BHT) > Centella asiatica > GE2 > GE1 > Moringa oleifera > Kelulut honey; the order of the mean FRAP value was as follows: NAC > a-tocopherol > BHT > TRF > Ficus deltoidea > Moringa oleifera > GE2 = GE1 > Centella asiatica > Kelulut honey. The viability assays showed that both ginger extracts significantly increased the percentage of viable cells (p < 0.05). In conclusion, neither of the ginger extracts was cytotoxic toward cells and both possessed comparable antioxidant properties, indicating their potential for ameliorating oxidative stress. Penerbit Universiti Kebangsaan Malaysia 2021 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/97276/1/MariamFirdhaus2021_ComparisonoftheAntioxidantActivityofMalaysianGinger.pdf Mohd. Sahardi, Nur Fatin Nabilah and Jaafar, Faizul and Zakaria, Siti Nor Asyikin and Tan, Jen Kit and Mad Nordin, Mariam Firdhaus and Makpol, Suzana (2021) Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture. Sains Malaysiana, 50 (5). pp. 1445-1456. ISSN 0126-6039 http://dx.doi.org/10.17576/jsm-2021-5005-23 DOI : 10.17576/jsm-2021-5005-23
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic T Technology (General)
spellingShingle T Technology (General)
Mohd. Sahardi, Nur Fatin Nabilah
Jaafar, Faizul
Zakaria, Siti Nor Asyikin
Tan, Jen Kit
Mad Nordin, Mariam Firdhaus
Makpol, Suzana
Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture
description Ginger has been proven to possess various therapeutic effects, including antibacterial, anticancer, anti-inflammatory, and antioxidant effects. However, data on the comparison of ginger antioxidant activity with that of other natural products are still lacking. This study aimed to analyse and compare the antioxidant properties of two types of Malaysian ginger extracts (GE1 and GE2) with that of selected natural products. The antioxidant activities were measured by 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and ferric reducing antioxidant power (FRAP) assays, while cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfonyl)-2H-tetrazolium (MTS) assay. The order of the DPPH scavenging activities was as follows: vitamin C > palm tocotrienol-rich fraction (TRF) > a-tocopherol > N-acetylcysteine (NAC) > Ficus deltoidea > butylated hydroxytoluene (BHT) > Centella asiatica > GE2 > GE1 > Moringa oleifera > Kelulut honey; the order of the mean FRAP value was as follows: NAC > a-tocopherol > BHT > TRF > Ficus deltoidea > Moringa oleifera > GE2 = GE1 > Centella asiatica > Kelulut honey. The viability assays showed that both ginger extracts significantly increased the percentage of viable cells (p < 0.05). In conclusion, neither of the ginger extracts was cytotoxic toward cells and both possessed comparable antioxidant properties, indicating their potential for ameliorating oxidative stress.
format Article
author Mohd. Sahardi, Nur Fatin Nabilah
Jaafar, Faizul
Zakaria, Siti Nor Asyikin
Tan, Jen Kit
Mad Nordin, Mariam Firdhaus
Makpol, Suzana
author_facet Mohd. Sahardi, Nur Fatin Nabilah
Jaafar, Faizul
Zakaria, Siti Nor Asyikin
Tan, Jen Kit
Mad Nordin, Mariam Firdhaus
Makpol, Suzana
author_sort Mohd. Sahardi, Nur Fatin Nabilah
title Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture
title_short Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture
title_full Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture
title_fullStr Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture
title_full_unstemmed Comparison of the antioxidant activity of Malaysian ginger (Zingiber officinale Roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture
title_sort comparison of the antioxidant activity of malaysian ginger (zingiber officinale roscoe) extracts with that of selected natural products and its effect on the viability of myoblast cells in culture
publisher Penerbit Universiti Kebangsaan Malaysia
publishDate 2021
url http://eprints.utm.my/id/eprint/97276/1/MariamFirdhaus2021_ComparisonoftheAntioxidantActivityofMalaysianGinger.pdf
http://eprints.utm.my/id/eprint/97276/
http://dx.doi.org/10.17576/jsm-2021-5005-23
_version_ 1745562360905465856
score 13.211869

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