Staff View: Metabolic response in rats following electroacupuncture or moxibustion stimulation

Metabolic response in rats following electroacupuncture or moxibustion stimulation

Electroacupuncture and moxibustion are traditional Chinese medicine practices that exert therapeutic effects through stimulation of specific meridian acupoints. However, the biological basis of the therapies has been difficult to establish; thus the current practices still rely on ancient TCM refere...

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Main Authors:	Xu, Jingjing, Lin, Xianwei, Cheng, Kian-Kai, Zhong, Huan, Liu, Mi, Zhang, Guoshan, Shen, Guiping, Dong, Jiyang
Format:	Article
Language:	English
Published:	Hindawi Limited 2019
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/96937/1/ChengKianKai2019_MetabolicResponseinRatsFollowingElectroacupuncture.pdf http://eprints.utm.my/id/eprint/96937/ http://dx.doi.org/10.1155/2019/6947471
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spelling	my.utm.969372022-09-04T07:15:23Z http://eprints.utm.my/id/eprint/96937/ Metabolic response in rats following electroacupuncture or moxibustion stimulation Xu, Jingjing Lin, Xianwei Cheng, Kian-Kai Zhong, Huan Liu, Mi Zhang, Guoshan Shen, Guiping Dong, Jiyang TP Chemical technology Electroacupuncture and moxibustion are traditional Chinese medicine practices that exert therapeutic effects through stimulation of specific meridian acupoints. However, the biological basis of the therapies has been difficult to establish; thus the current practices still rely on ancient TCM references. Here, we used a rat model to study perturbations in cortex, liver, and stomach metabolome and plasma hormones following electroacupuncture or moxibustion treatment on either stomach meridian or gallbladder meridian acupoints. All treatment groups, regardless of meridian and mode of treatment, showed perturbation in cortex metabolome and increased phenylalanine, tyrosine, and branched-chain amino acids in liver. In addition, electroacupuncture was found to increase ATP in cortex, creatine, and dimethylglycine in stomach and GABA in liver. On the other hand, moxibustion increased plasma enkephalin concentration, as well as betaine and fumarate concentrations in stomach. Furthermore, we had observed meridian-specific changes including increased N-acetyl-aspartate in liver and 3-hydroxybutyrate in stomach for gallbladder meridian stimulation and increased noradrenaline concentration in blood plasma following stimulation on stomach meridian. In summary, the current findings may provide insight into the metabolic basis of electroacupuncture and moxibustion, which may contribute towards new application of acupoint stimulation. Hindawi Limited 2019 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/96937/1/ChengKianKai2019_MetabolicResponseinRatsFollowingElectroacupuncture.pdf Xu, Jingjing and Lin, Xianwei and Cheng, Kian-Kai and Zhong, Huan and Liu, Mi and Zhang, Guoshan and Shen, Guiping and Dong, Jiyang (2019) Metabolic response in rats following electroacupuncture or moxibustion stimulation. Evidence-based Complementary and Alternative Medicine, 2019 (NA). pp. 1-14. ISSN 1741-427X http://dx.doi.org/10.1155/2019/6947471 DOI : 10.1155/2019/6947471
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Xu, Jingjing Lin, Xianwei Cheng, Kian-Kai Zhong, Huan Liu, Mi Zhang, Guoshan Shen, Guiping Dong, Jiyang Metabolic response in rats following electroacupuncture or moxibustion stimulation
description	Electroacupuncture and moxibustion are traditional Chinese medicine practices that exert therapeutic effects through stimulation of specific meridian acupoints. However, the biological basis of the therapies has been difficult to establish; thus the current practices still rely on ancient TCM references. Here, we used a rat model to study perturbations in cortex, liver, and stomach metabolome and plasma hormones following electroacupuncture or moxibustion treatment on either stomach meridian or gallbladder meridian acupoints. All treatment groups, regardless of meridian and mode of treatment, showed perturbation in cortex metabolome and increased phenylalanine, tyrosine, and branched-chain amino acids in liver. In addition, electroacupuncture was found to increase ATP in cortex, creatine, and dimethylglycine in stomach and GABA in liver. On the other hand, moxibustion increased plasma enkephalin concentration, as well as betaine and fumarate concentrations in stomach. Furthermore, we had observed meridian-specific changes including increased N-acetyl-aspartate in liver and 3-hydroxybutyrate in stomach for gallbladder meridian stimulation and increased noradrenaline concentration in blood plasma following stimulation on stomach meridian. In summary, the current findings may provide insight into the metabolic basis of electroacupuncture and moxibustion, which may contribute towards new application of acupoint stimulation.
format	Article
author	Xu, Jingjing Lin, Xianwei Cheng, Kian-Kai Zhong, Huan Liu, Mi Zhang, Guoshan Shen, Guiping Dong, Jiyang
author_facet	Xu, Jingjing Lin, Xianwei Cheng, Kian-Kai Zhong, Huan Liu, Mi Zhang, Guoshan Shen, Guiping Dong, Jiyang
author_sort	Xu, Jingjing
title	Metabolic response in rats following electroacupuncture or moxibustion stimulation
title_short	Metabolic response in rats following electroacupuncture or moxibustion stimulation
title_full	Metabolic response in rats following electroacupuncture or moxibustion stimulation
title_fullStr	Metabolic response in rats following electroacupuncture or moxibustion stimulation
title_full_unstemmed	Metabolic response in rats following electroacupuncture or moxibustion stimulation
title_sort	metabolic response in rats following electroacupuncture or moxibustion stimulation
publisher	Hindawi Limited
publishDate	2019
url	http://eprints.utm.my/id/eprint/96937/1/ChengKianKai2019_MetabolicResponseinRatsFollowingElectroacupuncture.pdf http://eprints.utm.my/id/eprint/96937/ http://dx.doi.org/10.1155/2019/6947471
_version_	1743107048565899264
score	13.211869

Metabolic response in rats following electroacupuncture or moxibustion stimulation

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