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Fabrication, characterization and degradation of electrospun poly(ε-Caprolactone) infused with selenium nanoparticles

Polycaprolactone (PCL) is widely used in the fabrication of nanofibers through the electrospinning technique. PCL is a biodegradable material that is economical, simple and can be scaled up for industrial production. In this study, PCL was infused with selenium nanoparticles (SeNPs) via electrospinn...

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Main Authors: Kamaruzaman, Nurul Asyikin, Mohd. Yusoff, Abdull Rahim, Nik Malek, Nik Ahmad Nizam, Talib, Marina
Format: Article
Language:English
Published: Penerbit UTM Press 2021
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/id/eprint/96599/1/AbdullRahim2021_FabricationCharacterizationandDegradationofElectrospunPoly.pdf
http://eprints.utm.my/id/eprint/96599/
http://dx.doi.org/10.11113/MJFAS.V17N3.2183
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spelling my.utm.965992022-08-08T04:08:55Z http://eprints.utm.my/id/eprint/96599/ Fabrication, characterization and degradation of electrospun poly(ε-Caprolactone) infused with selenium nanoparticles Kamaruzaman, Nurul Asyikin Mohd. Yusoff, Abdull Rahim Nik Malek, Nik Ahmad Nizam Talib, Marina QD Chemistry Polycaprolactone (PCL) is widely used in the fabrication of nanofibers through the electrospinning technique. PCL is a biodegradable material that is economical, simple and can be scaled up for industrial production. In this study, PCL was infused with selenium nanoparticles (SeNPs) via electrospinning to fabricate PCL-SeNPs nanofiber. Field emission scanning electron microscopy (FESEM) images of the samples revealed 'aligned fibers' were successfully fabricated with a diameter of less than 350 nm and an average diameter of 185 nm. The presence of Se in the nanofiber was confirmed by energy dispersive X-ray analysis (EDX) and Raman spectra. Based on the X-ray diffraction (XRD) pattern, the structure of PCL did not change and remained in the PCL-SeNPs nanofibers. As indicated by infrared (IR) spectra, the functional groups of PCL remained the same after SeNPs infusion. These results demonstrated that PCL nanofibers' physical and chemical properties were not affected by the infusion of SeNPs. In addition, the hydrophobicity of the PCL decreased slightly in the presence of SeNPs. The first month after degradation, disorganized and fibrous fibers of PCL-SeNPs nanofiber were observed, followed by the formation of large fiber clumps as degradation time increased. An agglomerated SeNPs made PCL-SeNPs nanofiber pores looser and easier to be hydrolyzed after four months of degradation. The sticky surface of PCL-SeNPs nanofiber shows acceleration in the hydrolysis process after 24th weeks of degradation. The presence of SeNPs enhanced the degradation behavior and reduced the degradation time to break into pieces, starting after six months of degradation. The 'aligned' PCL-SeNPs nanofiber, which can mimic the natural tissue extracellular matrix (ECM) morphology, can potentially be used in biomedical applications such as tissue engineering, wound dressing, biomedicine, sensor and filtration application. Penerbit UTM Press 2021 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/96599/1/AbdullRahim2021_FabricationCharacterizationandDegradationofElectrospunPoly.pdf Kamaruzaman, Nurul Asyikin and Mohd. Yusoff, Abdull Rahim and Nik Malek, Nik Ahmad Nizam and Talib, Marina (2021) Fabrication, characterization and degradation of electrospun poly(ε-Caprolactone) infused with selenium nanoparticles. Malaysian Journal of Fundamental and Applied Sciences, 17 (3). pp. 295-305. ISSN 2289-599X http://dx.doi.org/10.11113/MJFAS.V17N3.2183 DOI:10.11113/MJFAS.V17N3.2183
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Kamaruzaman, Nurul Asyikin
Mohd. Yusoff, Abdull Rahim
Nik Malek, Nik Ahmad Nizam
Talib, Marina
Fabrication, characterization and degradation of electrospun poly(ε-Caprolactone) infused with selenium nanoparticles
description Polycaprolactone (PCL) is widely used in the fabrication of nanofibers through the electrospinning technique. PCL is a biodegradable material that is economical, simple and can be scaled up for industrial production. In this study, PCL was infused with selenium nanoparticles (SeNPs) via electrospinning to fabricate PCL-SeNPs nanofiber. Field emission scanning electron microscopy (FESEM) images of the samples revealed 'aligned fibers' were successfully fabricated with a diameter of less than 350 nm and an average diameter of 185 nm. The presence of Se in the nanofiber was confirmed by energy dispersive X-ray analysis (EDX) and Raman spectra. Based on the X-ray diffraction (XRD) pattern, the structure of PCL did not change and remained in the PCL-SeNPs nanofibers. As indicated by infrared (IR) spectra, the functional groups of PCL remained the same after SeNPs infusion. These results demonstrated that PCL nanofibers' physical and chemical properties were not affected by the infusion of SeNPs. In addition, the hydrophobicity of the PCL decreased slightly in the presence of SeNPs. The first month after degradation, disorganized and fibrous fibers of PCL-SeNPs nanofiber were observed, followed by the formation of large fiber clumps as degradation time increased. An agglomerated SeNPs made PCL-SeNPs nanofiber pores looser and easier to be hydrolyzed after four months of degradation. The sticky surface of PCL-SeNPs nanofiber shows acceleration in the hydrolysis process after 24th weeks of degradation. The presence of SeNPs enhanced the degradation behavior and reduced the degradation time to break into pieces, starting after six months of degradation. The 'aligned' PCL-SeNPs nanofiber, which can mimic the natural tissue extracellular matrix (ECM) morphology, can potentially be used in biomedical applications such as tissue engineering, wound dressing, biomedicine, sensor and filtration application.
format Article
author Kamaruzaman, Nurul Asyikin
Mohd. Yusoff, Abdull Rahim
Nik Malek, Nik Ahmad Nizam
Talib, Marina
author_facet Kamaruzaman, Nurul Asyikin
Mohd. Yusoff, Abdull Rahim
Nik Malek, Nik Ahmad Nizam
Talib, Marina
author_sort Kamaruzaman, Nurul Asyikin
title Fabrication, characterization and degradation of electrospun poly(ε-Caprolactone) infused with selenium nanoparticles
title_short Fabrication, characterization and degradation of electrospun poly(ε-Caprolactone) infused with selenium nanoparticles
title_full Fabrication, characterization and degradation of electrospun poly(ε-Caprolactone) infused with selenium nanoparticles
title_fullStr Fabrication, characterization and degradation of electrospun poly(ε-Caprolactone) infused with selenium nanoparticles
title_full_unstemmed Fabrication, characterization and degradation of electrospun poly(ε-Caprolactone) infused with selenium nanoparticles
title_sort fabrication, characterization and degradation of electrospun poly(ε-caprolactone) infused with selenium nanoparticles
publisher Penerbit UTM Press
publishDate 2021
url http://eprints.utm.my/id/eprint/96599/1/AbdullRahim2021_FabricationCharacterizationandDegradationofElectrospunPoly.pdf
http://eprints.utm.my/id/eprint/96599/
http://dx.doi.org/10.11113/MJFAS.V17N3.2183
_version_ 1740825680180936704
score 13.211869

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