Staff View: Nanocomposite hydrogels for melanoma skin cancer care and treatment: In-vitro drug delivery, drug release kinetics and anti-cancer activities

Nanocomposite hydrogels for melanoma skin cancer care and treatment: In-vitro drug delivery, drug release kinetics and anti-cancer activities

Malignant melanoma is a lethal human skin cancer that is not easily treatable through traditional medicines, surgeries, and therapies. Millions of cases are recorded annually to cure physiological skin defects by chemotherapy that causes several adverse effects and challenges. Moreover, pathogenic i...

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Main Authors:	Nazir, Samina, Aslam Khan, Muhammad Umar, Al-Arjan, Wafa Shamsan, Abd. Razak, Saiful Izwan, Javed, Aneela, Abdul Kadir, Mohammed Rafiq
Format:	Article
Published:	Elsevier B.V. 2021
Subjects:	QH301 Biology
Online Access:	http://eprints.utm.my/id/eprint/95809/ http://dx.doi.org/10.1016/j.arabjc.2021.103120
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spelling	my.utm.958092022-05-31T13:19:31Z http://eprints.utm.my/id/eprint/95809/ Nanocomposite hydrogels for melanoma skin cancer care and treatment: In-vitro drug delivery, drug release kinetics and anti-cancer activities Nazir, Samina Aslam Khan, Muhammad Umar Al-Arjan, Wafa Shamsan Abd. Razak, Saiful Izwan Javed, Aneela Abdul Kadir, Mohammed Rafiq QH301 Biology Malignant melanoma is a lethal human skin cancer that is not easily treatable through traditional medicines, surgeries, and therapies. Millions of cases are recorded annually to cure physiological skin defects by chemotherapy that causes several adverse effects and challenges. Moreover, pathogenic infections might aggravate infection with subsequent ulceration or cutaneous melanoma. Accordingly, we synthesized nanodrug by loading chemotherapeutic agent, Fluorouracil (5FU), onto the reduced graphene oxide (rGO). We then extracted arabinoxylan (ARX) from the husk of Plantago Ovata and functionalized it into carboxymethylarabinoxylan (CMARX) and loaded synthesized nanodrug. We have crosslinked CMARX/nanodrug with different amount of tetraethylorthosilicate (TEOS) to prepare nanocomposite hydrogel rGO-5FU-CMARX system for melanoma skin cancer care and treatment. These nanocomposite hydrogel systems rGO-5FU-CMARX have exhibited different physicochemical properties. These properties were analyzed through FTIR, SEM, water contact angle, swelling in different media (aqueous and PBS) and biodegradation in PBS media. The in-vitro activities, i.e., drug delivery via Franz diffusion, antibacterial against S. aureus and P. aeruginosa and the anticancer activities was performed against Uppsala 87 Malignant Glioma (U-87) cell lines. Moreover, rGO-5FU-CMARX nanocomposite hydrogels displayed different antimicrobial and anticancer activities based on different crosslinking. Hence, an inventive rGO-5FU-CMARX based nanocomposite hydrogel drug-delivery system was developed to treat malignant melanoma skin cancer after bacterial infections. Elsevier B.V. 2021 Article PeerReviewed Nazir, Samina and Aslam Khan, Muhammad Umar and Al-Arjan, Wafa Shamsan and Abd. Razak, Saiful Izwan and Javed, Aneela and Abdul Kadir, Mohammed Rafiq (2021) Nanocomposite hydrogels for melanoma skin cancer care and treatment: In-vitro drug delivery, drug release kinetics and anti-cancer activities. Arabian Journal of Chemistry, 14 (5). p. 103120. ISSN 1878-5352 http://dx.doi.org/10.1016/j.arabjc.2021.103120
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	QH301 Biology
spellingShingle	QH301 Biology Nazir, Samina Aslam Khan, Muhammad Umar Al-Arjan, Wafa Shamsan Abd. Razak, Saiful Izwan Javed, Aneela Abdul Kadir, Mohammed Rafiq Nanocomposite hydrogels for melanoma skin cancer care and treatment: In-vitro drug delivery, drug release kinetics and anti-cancer activities
description	Malignant melanoma is a lethal human skin cancer that is not easily treatable through traditional medicines, surgeries, and therapies. Millions of cases are recorded annually to cure physiological skin defects by chemotherapy that causes several adverse effects and challenges. Moreover, pathogenic infections might aggravate infection with subsequent ulceration or cutaneous melanoma. Accordingly, we synthesized nanodrug by loading chemotherapeutic agent, Fluorouracil (5FU), onto the reduced graphene oxide (rGO). We then extracted arabinoxylan (ARX) from the husk of Plantago Ovata and functionalized it into carboxymethylarabinoxylan (CMARX) and loaded synthesized nanodrug. We have crosslinked CMARX/nanodrug with different amount of tetraethylorthosilicate (TEOS) to prepare nanocomposite hydrogel rGO-5FU-CMARX system for melanoma skin cancer care and treatment. These nanocomposite hydrogel systems rGO-5FU-CMARX have exhibited different physicochemical properties. These properties were analyzed through FTIR, SEM, water contact angle, swelling in different media (aqueous and PBS) and biodegradation in PBS media. The in-vitro activities, i.e., drug delivery via Franz diffusion, antibacterial against S. aureus and P. aeruginosa and the anticancer activities was performed against Uppsala 87 Malignant Glioma (U-87) cell lines. Moreover, rGO-5FU-CMARX nanocomposite hydrogels displayed different antimicrobial and anticancer activities based on different crosslinking. Hence, an inventive rGO-5FU-CMARX based nanocomposite hydrogel drug-delivery system was developed to treat malignant melanoma skin cancer after bacterial infections.
format	Article
author	Nazir, Samina Aslam Khan, Muhammad Umar Al-Arjan, Wafa Shamsan Abd. Razak, Saiful Izwan Javed, Aneela Abdul Kadir, Mohammed Rafiq
author_facet	Nazir, Samina Aslam Khan, Muhammad Umar Al-Arjan, Wafa Shamsan Abd. Razak, Saiful Izwan Javed, Aneela Abdul Kadir, Mohammed Rafiq
author_sort	Nazir, Samina
title	Nanocomposite hydrogels for melanoma skin cancer care and treatment: In-vitro drug delivery, drug release kinetics and anti-cancer activities
title_short	Nanocomposite hydrogels for melanoma skin cancer care and treatment: In-vitro drug delivery, drug release kinetics and anti-cancer activities
title_full	Nanocomposite hydrogels for melanoma skin cancer care and treatment: In-vitro drug delivery, drug release kinetics and anti-cancer activities
title_fullStr	Nanocomposite hydrogels for melanoma skin cancer care and treatment: In-vitro drug delivery, drug release kinetics and anti-cancer activities
title_full_unstemmed	Nanocomposite hydrogels for melanoma skin cancer care and treatment: In-vitro drug delivery, drug release kinetics and anti-cancer activities
title_sort	nanocomposite hydrogels for melanoma skin cancer care and treatment: in-vitro drug delivery, drug release kinetics and anti-cancer activities
publisher	Elsevier B.V.
publishDate	2021
url	http://eprints.utm.my/id/eprint/95809/ http://dx.doi.org/10.1016/j.arabjc.2021.103120
_version_	1735386849928544256
score	13.211869

Nanocomposite hydrogels for melanoma skin cancer care and treatment: In-vitro drug delivery, drug release kinetics and anti-cancer activities

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