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Degradation-triggered release from biodegradable metallic surfaces

This work is dedicated to the investigation of drug-release control by a direct effect of degradation from biodegradable metallic surfaces. Degradation behaviors characterized by surface morphology, immersion, and electrochemical techniques demonstrated that curcumin-coated zinc (c-Zn) had a higher...

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Main Authors:	Md. Yusop, A. H., Alsakkaf, A., Noordin, M. A., Idris, H., Nur, H., Januddi, F. S.
Format:	Article
Published:	John Wiley and Sons Inc 2021
Subjects:	Q Science (General)
Online Access:	http://eprints.utm.my/id/eprint/95338/ http://dx.doi.org/10.1002/jbm.b.34866
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id	my.utm.95338
record_format	eprints
spelling	my.utm.953382022-04-29T22:04:31Z http://eprints.utm.my/id/eprint/95338/ Degradation-triggered release from biodegradable metallic surfaces Md. Yusop, A. H. Alsakkaf, A. Noordin, M. A. Idris, H. Nur, H. Januddi, F. S. Q Science (General) This work is dedicated to the investigation of drug-release control by a direct effect of degradation from biodegradable metallic surfaces. Degradation behaviors characterized by surface morphology, immersion, and electrochemical techniques demonstrated that curcumin-coated zinc (c-Zn) had a higher degradation rate compared to curcumin-coated Fe (c-Fe). High anodic dissolution rate due to the higher degradation rate and widely extended groove-like degradation structure of c-Zn propelled a higher curcumin release. On the other hand, a slower curcumin release rate shown by c-Fe scaffolds is ascribed to its lower anodic dissolution and to its pitting degradation regime with relatively smaller pits. These findings illuminate the remarkable advantage of different degradation behaviors of degradable metallic surfaces in directly controlling the drug release without the need for external electrical stimulus. John Wiley and Sons Inc 2021 Article PeerReviewed Md. Yusop, A. H. and Alsakkaf, A. and Noordin, M. A. and Idris, H. and Nur, H. and Januddi, F. S. (2021) Degradation-triggered release from biodegradable metallic surfaces. Journal of Biomedical Materials Research - Part B Applied Biomaterial, 109 (12). ISSN 1552-4973 http://dx.doi.org/10.1002/jbm.b.34866 DOI: 10.1002/jbm.b.34866
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
topic	Q Science (General)
spellingShingle	Q Science (General) Md. Yusop, A. H. Alsakkaf, A. Noordin, M. A. Idris, H. Nur, H. Januddi, F. S. Degradation-triggered release from biodegradable metallic surfaces
description	This work is dedicated to the investigation of drug-release control by a direct effect of degradation from biodegradable metallic surfaces. Degradation behaviors characterized by surface morphology, immersion, and electrochemical techniques demonstrated that curcumin-coated zinc (c-Zn) had a higher degradation rate compared to curcumin-coated Fe (c-Fe). High anodic dissolution rate due to the higher degradation rate and widely extended groove-like degradation structure of c-Zn propelled a higher curcumin release. On the other hand, a slower curcumin release rate shown by c-Fe scaffolds is ascribed to its lower anodic dissolution and to its pitting degradation regime with relatively smaller pits. These findings illuminate the remarkable advantage of different degradation behaviors of degradable metallic surfaces in directly controlling the drug release without the need for external electrical stimulus.
format	Article
author	Md. Yusop, A. H. Alsakkaf, A. Noordin, M. A. Idris, H. Nur, H. Januddi, F. S.
author_facet	Md. Yusop, A. H. Alsakkaf, A. Noordin, M. A. Idris, H. Nur, H. Januddi, F. S.
author_sort	Md. Yusop, A. H.
title	Degradation-triggered release from biodegradable metallic surfaces
title_short	Degradation-triggered release from biodegradable metallic surfaces
title_full	Degradation-triggered release from biodegradable metallic surfaces
title_fullStr	Degradation-triggered release from biodegradable metallic surfaces
title_full_unstemmed	Degradation-triggered release from biodegradable metallic surfaces
title_sort	degradation-triggered release from biodegradable metallic surfaces
publisher	John Wiley and Sons Inc
publishDate	2021
url	http://eprints.utm.my/id/eprint/95338/ http://dx.doi.org/10.1002/jbm.b.34866
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score	13.211869

Degradation-triggered release from biodegradable metallic surfaces

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