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Investigation on downstream processing of industrial scale of flexirubin production using superpro designer

The aim of this work is to utilize a process simulator SuperPro Designer v5.5 (Intelligent, NJ, USA) for investigation on the most optimum scenario for the recovery of flexirubin pigment that was produced from a fermentation process using Chryseobacterium artocarpi strain. Process flow sheeting was...

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Main Authors: Arriafdi, Muhammad Zainuddin, Sani, Mohd. Helmi, Ahmad, Wan Azlina, Zainal Alam, Muhd. Nazrul Hisham
Format: Article
Language:English
Published: Penerbit UTM Press 2021
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/95128/1/MuhdNazrulHisham2021_InvestigationOnDownstreamProcessingOfIndustrialScale.pdf
http://eprints.utm.my/id/eprint/95128/
http://dx.doi.org/10.11113/jurnalteknologi.v83.14688
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spelling my.utm.951282022-04-29T22:24:21Z http://eprints.utm.my/id/eprint/95128/ Investigation on downstream processing of industrial scale of flexirubin production using superpro designer Arriafdi, Muhammad Zainuddin Sani, Mohd. Helmi Ahmad, Wan Azlina Zainal Alam, Muhd. Nazrul Hisham TP Chemical technology The aim of this work is to utilize a process simulator SuperPro Designer v5.5 (Intelligent, NJ, USA) for investigation on the most optimum scenario for the recovery of flexirubin pigment that was produced from a fermentation process using Chryseobacterium artocarpi strain. Process flow sheeting was based on the production of 300 kg per annum of flexirubin. Production phase at 1000 L bioreactor (including steps for the inoculum development) and different scenarios/routes for recovery of flexirubin were considered. SuperPro designer process simulator allowed for the computation of overall operating cost and capital cost under various operating parameters. Results from simulation shows that all proposed downstream processing routes is capable of achieving a high degree of flexirubin recovery yield i.e. at least 94% (or greater). Operating cost was relatively low as the overall quantity of flexirubin was rather small. Capital cost for equipment purchasing however highly depending on the selection of unit procedures for recovery of flexirubin. Centrifugation unit accelerated the separation processes but it is costly compared to the dead-end filtration unit. The latter was found to be the bottleneck for the optimization step where high yield of flexirubin can be warranted at reduced capital cost by at least 40%. Penerbit UTM Press 2021 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/95128/1/MuhdNazrulHisham2021_InvestigationOnDownstreamProcessingOfIndustrialScale.pdf Arriafdi, Muhammad Zainuddin and Sani, Mohd. Helmi and Ahmad, Wan Azlina and Zainal Alam, Muhd. Nazrul Hisham (2021) Investigation on downstream processing of industrial scale of flexirubin production using superpro designer. Jurnal Teknologi, 83 (2). pp. 37-45. ISSN 0127-9696 http://dx.doi.org/10.11113/jurnalteknologi.v83.14688
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Arriafdi, Muhammad Zainuddin
Sani, Mohd. Helmi
Ahmad, Wan Azlina
Zainal Alam, Muhd. Nazrul Hisham
Investigation on downstream processing of industrial scale of flexirubin production using superpro designer
description The aim of this work is to utilize a process simulator SuperPro Designer v5.5 (Intelligent, NJ, USA) for investigation on the most optimum scenario for the recovery of flexirubin pigment that was produced from a fermentation process using Chryseobacterium artocarpi strain. Process flow sheeting was based on the production of 300 kg per annum of flexirubin. Production phase at 1000 L bioreactor (including steps for the inoculum development) and different scenarios/routes for recovery of flexirubin were considered. SuperPro designer process simulator allowed for the computation of overall operating cost and capital cost under various operating parameters. Results from simulation shows that all proposed downstream processing routes is capable of achieving a high degree of flexirubin recovery yield i.e. at least 94% (or greater). Operating cost was relatively low as the overall quantity of flexirubin was rather small. Capital cost for equipment purchasing however highly depending on the selection of unit procedures for recovery of flexirubin. Centrifugation unit accelerated the separation processes but it is costly compared to the dead-end filtration unit. The latter was found to be the bottleneck for the optimization step where high yield of flexirubin can be warranted at reduced capital cost by at least 40%.
format Article
author Arriafdi, Muhammad Zainuddin
Sani, Mohd. Helmi
Ahmad, Wan Azlina
Zainal Alam, Muhd. Nazrul Hisham
author_facet Arriafdi, Muhammad Zainuddin
Sani, Mohd. Helmi
Ahmad, Wan Azlina
Zainal Alam, Muhd. Nazrul Hisham
author_sort Arriafdi, Muhammad Zainuddin
title Investigation on downstream processing of industrial scale of flexirubin production using superpro designer
title_short Investigation on downstream processing of industrial scale of flexirubin production using superpro designer
title_full Investigation on downstream processing of industrial scale of flexirubin production using superpro designer
title_fullStr Investigation on downstream processing of industrial scale of flexirubin production using superpro designer
title_full_unstemmed Investigation on downstream processing of industrial scale of flexirubin production using superpro designer
title_sort investigation on downstream processing of industrial scale of flexirubin production using superpro designer
publisher Penerbit UTM Press
publishDate 2021
url http://eprints.utm.my/id/eprint/95128/1/MuhdNazrulHisham2021_InvestigationOnDownstreamProcessingOfIndustrialScale.pdf
http://eprints.utm.my/id/eprint/95128/
http://dx.doi.org/10.11113/jurnalteknologi.v83.14688
_version_ 1732945435594588160
score 13.211869

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