Staff View: Potential of stimuli-responsive in situ gel system for sustained ocular drug delivery: recent progress and contemporary research

Potential of stimuli-responsive in situ gel system for sustained ocular drug delivery: recent progress and contemporary research

Eyesight is one of the most well-deserved blessings, amid all the five senses in the human body. It captures the raw signals from the outside world to create detailed visual images, granting the ability to witness and gain knowledge about the world. Eyes are exposed directly to the external environm...

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Main Authors:	Pandey, M., Choudhury, H., Abd. Aziz, A., Bhattamisra, S. K., Gorain, B., Su, J. S. T., Tan, C. L., Chin, W. Y., Yip, Y. K.
Format:	Article
Language:	English
Published:	MDPI AG 2021
Subjects:	T Technology (General)
Online Access:	http://eprints.utm.my/id/eprint/95018/1/AzilaAbdAziz2021_PotentialofStimuliResponsiveInSitu.pdf http://eprints.utm.my/id/eprint/95018/ http://dx.doi.org/10.3390/polym13081340
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spelling	my.utm.950182022-04-29T22:01:23Z http://eprints.utm.my/id/eprint/95018/ Potential of stimuli-responsive in situ gel system for sustained ocular drug delivery: recent progress and contemporary research Pandey, M. Choudhury, H. Abd. Aziz, A. Bhattamisra, S. K. Gorain, B. Su, J. S. T. Tan, C. L. Chin, W. Y. Yip, Y. K. T Technology (General) Eyesight is one of the most well-deserved blessings, amid all the five senses in the human body. It captures the raw signals from the outside world to create detailed visual images, granting the ability to witness and gain knowledge about the world. Eyes are exposed directly to the external environment; they are susceptible to the vicissitudes of diseases. The World Health Organization has predicted that the number of individuals affected by eye diseases will rise enormously in the next decades. However, the physical barriers of the eyes and the problems associated with conventional ocular formulations are significant challenges in ophthalmic drug development. This has generated the demand for a sustained ocular drug delivery system, which serves to deliver effective drug concentration at a reduced frequency for consistent therapeutic effect and better patient treatment adherence. Recent advancement in pharmaceutical dosage design has demonstrated that a stimuli-responsive in situ gel system exhibits the favorable characteristics for providing sustained ocular drug delivery and enhanced ocular bioavailability. Stimuli-responsive in situ gels undergo a phase transition (solution–gelation) in response to the ocular environmental temperature, pH, and ions. These stimuli transform the formulation into a gel at the cul de sac to overcome the shortcomings of conventional eye drops, such as rapid nasolacrimal drainage and short contact time with the ocular surface This review highlights the recent successful research outcomes of stimuli-responsive in situ gelling systems in treating in vivo models with glaucoma and various ocular infections. Additionally, it also presents the mechanism, recent development, and safety considerations of stimuli-sensitive in situ gel as the potential sustained ocular delivery system for treating common eye disorders. MDPI AG 2021 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/95018/1/AzilaAbdAziz2021_PotentialofStimuliResponsiveInSitu.pdf Pandey, M. and Choudhury, H. and Abd. Aziz, A. and Bhattamisra, S. K. and Gorain, B. and Su, J. S. T. and Tan, C. L. and Chin, W. Y. and Yip, Y. K. (2021) Potential of stimuli-responsive in situ gel system for sustained ocular drug delivery: recent progress and contemporary research. Polymers, 13 (8). ISSN 2073-4360 http://dx.doi.org/10.3390/polym13081340 DOI: 10.3390/polym13081340
institution	Universiti Teknologi Malaysia
building	UTM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Teknologi Malaysia
content_source	UTM Institutional Repository
url_provider	http://eprints.utm.my/
language	English
topic	T Technology (General)
spellingShingle	T Technology (General) Pandey, M. Choudhury, H. Abd. Aziz, A. Bhattamisra, S. K. Gorain, B. Su, J. S. T. Tan, C. L. Chin, W. Y. Yip, Y. K. Potential of stimuli-responsive in situ gel system for sustained ocular drug delivery: recent progress and contemporary research
description	Eyesight is one of the most well-deserved blessings, amid all the five senses in the human body. It captures the raw signals from the outside world to create detailed visual images, granting the ability to witness and gain knowledge about the world. Eyes are exposed directly to the external environment; they are susceptible to the vicissitudes of diseases. The World Health Organization has predicted that the number of individuals affected by eye diseases will rise enormously in the next decades. However, the physical barriers of the eyes and the problems associated with conventional ocular formulations are significant challenges in ophthalmic drug development. This has generated the demand for a sustained ocular drug delivery system, which serves to deliver effective drug concentration at a reduced frequency for consistent therapeutic effect and better patient treatment adherence. Recent advancement in pharmaceutical dosage design has demonstrated that a stimuli-responsive in situ gel system exhibits the favorable characteristics for providing sustained ocular drug delivery and enhanced ocular bioavailability. Stimuli-responsive in situ gels undergo a phase transition (solution–gelation) in response to the ocular environmental temperature, pH, and ions. These stimuli transform the formulation into a gel at the cul de sac to overcome the shortcomings of conventional eye drops, such as rapid nasolacrimal drainage and short contact time with the ocular surface This review highlights the recent successful research outcomes of stimuli-responsive in situ gelling systems in treating in vivo models with glaucoma and various ocular infections. Additionally, it also presents the mechanism, recent development, and safety considerations of stimuli-sensitive in situ gel as the potential sustained ocular delivery system for treating common eye disorders.
format	Article
author	Pandey, M. Choudhury, H. Abd. Aziz, A. Bhattamisra, S. K. Gorain, B. Su, J. S. T. Tan, C. L. Chin, W. Y. Yip, Y. K.
author_facet	Pandey, M. Choudhury, H. Abd. Aziz, A. Bhattamisra, S. K. Gorain, B. Su, J. S. T. Tan, C. L. Chin, W. Y. Yip, Y. K.
author_sort	Pandey, M.
title	Potential of stimuli-responsive in situ gel system for sustained ocular drug delivery: recent progress and contemporary research
title_short	Potential of stimuli-responsive in situ gel system for sustained ocular drug delivery: recent progress and contemporary research
title_full	Potential of stimuli-responsive in situ gel system for sustained ocular drug delivery: recent progress and contemporary research
title_fullStr	Potential of stimuli-responsive in situ gel system for sustained ocular drug delivery: recent progress and contemporary research
title_full_unstemmed	Potential of stimuli-responsive in situ gel system for sustained ocular drug delivery: recent progress and contemporary research
title_sort	potential of stimuli-responsive in situ gel system for sustained ocular drug delivery: recent progress and contemporary research
publisher	MDPI AG
publishDate	2021
url	http://eprints.utm.my/id/eprint/95018/1/AzilaAbdAziz2021_PotentialofStimuliResponsiveInSitu.pdf http://eprints.utm.my/id/eprint/95018/ http://dx.doi.org/10.3390/polym13081340
_version_	1732945422111997952
score	13.211869

Potential of stimuli-responsive in situ gel system for sustained ocular drug delivery: recent progress and contemporary research

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