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5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment

Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-fluorouracil carrier abbreviated as MC/5-FU for potential colorectal...

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Main Authors: Yusefi, M., Kiun, M. S. L., Shameli, K., Teow, S. Y., Ali, R. R., Siew, K. K., Chan, H. Y., Wong, M. M. T., Lim, W. L.
Format: Article
Language:English
Published: Elsevier Ltd. 2021
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/94936/1/MostafaYusefi2021_5-FluorouracilLoadedMagneticCellulose.pdf
http://eprints.utm.my/id/eprint/94936/
http://dx.doi.org/10.1016/j.carbpol.2021.118523
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spelling my.utm.949362022-04-29T21:55:09Z http://eprints.utm.my/id/eprint/94936/ 5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment Yusefi, M. Kiun, M. S. L. Shameli, K. Teow, S. Y. Ali, R. R. Siew, K. K. Chan, H. Y. Wong, M. M. T. Lim, W. L. TP Chemical technology Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-fluorouracil carrier abbreviated as MC/5-FU for potential colorectal cancer treatments. Several analyses indicated the multifunctional properties of MC/5-FU bionanocomposites. Transmission and scanning electron microscopy study demonstrated that Fe3O4 nanofillers covered the cellulose matrix. The drug release from MC/5-FU was evaluated under various pH and temperature conditions, showing the maximum release at pH 7.4 and 44.2 °C. In in vitro anticancer assay, MC/5-FU exhibited enhanced selectivity and anticancer actions against 2D monolayer and 3D tumour spheroid models colorectal cancer cells. The anticancer effects of MC/5-FU with magnetic targeting and heat induction were also examined. This easily synthesized MC/5-FU indicated the potential in application as a low-cost drug formulation for colorectal cancer treatments. Elsevier Ltd. 2021 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/94936/1/MostafaYusefi2021_5-FluorouracilLoadedMagneticCellulose.pdf Yusefi, M. and Kiun, M. S. L. and Shameli, K. and Teow, S. Y. and Ali, R. R. and Siew, K. K. and Chan, H. Y. and Wong, M. M. T. and Lim, W. L. (2021) 5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment. Carbohydrate Polymers, 273 . ISSN 0144-8617 http://dx.doi.org/10.1016/j.carbpol.2021.118523 DOI: 10.1016/j.carbpol.2021.118523
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Yusefi, M.
Kiun, M. S. L.
Shameli, K.
Teow, S. Y.
Ali, R. R.
Siew, K. K.
Chan, H. Y.
Wong, M. M. T.
Lim, W. L.
5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment
description Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, Fe3O4-nanoparticles were supported on rice straw cellulose for 5-fluorouracil carrier abbreviated as MC/5-FU for potential colorectal cancer treatments. Several analyses indicated the multifunctional properties of MC/5-FU bionanocomposites. Transmission and scanning electron microscopy study demonstrated that Fe3O4 nanofillers covered the cellulose matrix. The drug release from MC/5-FU was evaluated under various pH and temperature conditions, showing the maximum release at pH 7.4 and 44.2 °C. In in vitro anticancer assay, MC/5-FU exhibited enhanced selectivity and anticancer actions against 2D monolayer and 3D tumour spheroid models colorectal cancer cells. The anticancer effects of MC/5-FU with magnetic targeting and heat induction were also examined. This easily synthesized MC/5-FU indicated the potential in application as a low-cost drug formulation for colorectal cancer treatments.
format Article
author Yusefi, M.
Kiun, M. S. L.
Shameli, K.
Teow, S. Y.
Ali, R. R.
Siew, K. K.
Chan, H. Y.
Wong, M. M. T.
Lim, W. L.
author_facet Yusefi, M.
Kiun, M. S. L.
Shameli, K.
Teow, S. Y.
Ali, R. R.
Siew, K. K.
Chan, H. Y.
Wong, M. M. T.
Lim, W. L.
author_sort Yusefi, M.
title 5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment
title_short 5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment
title_full 5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment
title_fullStr 5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment
title_full_unstemmed 5-Fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment
title_sort 5-fluorouracil loaded magnetic cellulose bionanocomposites for potential colorectal cancer treatment
publisher Elsevier Ltd.
publishDate 2021
url http://eprints.utm.my/id/eprint/94936/1/MostafaYusefi2021_5-FluorouracilLoadedMagneticCellulose.pdf
http://eprints.utm.my/id/eprint/94936/
http://dx.doi.org/10.1016/j.carbpol.2021.118523
_version_ 1732945412166254592
score 13.211869

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